000131451 001__ 131451
000131451 005__ 20240209155915.0
000131451 0247_ $$2doi$$a10.1016/j.jacc.2015.12.056
000131451 0248_ $$2sideral$$a94661
000131451 037__ $$aART-2016-94661
000131451 041__ $$aeng
000131451 100__ $$0(orcid)0000-0003-3963-0846$$aLaclaustra, M.
000131451 245__ $$aFemoral and carotid subclinical atherosclerosis association with risk factors and coronary calcium: The AWHS study
000131451 260__ $$c2016
000131451 5203_ $$aBackground: Early subclinical atherosclerosis has been mainly researched in carotid arteries. The potential value of femoral arteries for improving the predictive capacity of traditional risk factors is an understudied area. 
Objectives: This study sought to evaluate the association of subclinical carotid and femoral plaques with risk factors and coronary artery calcium score (CACS) in middle-aged men. Methods Participants (n = 1,423) of the AWHS (Aragon Workers'' Health Study), a study designed to assess cardiovascular risk and subclinical atherosclerosis in a cohort of middle-aged men (40 to 59 years of age), underwent carotid and femoral ultrasound plus noncontrast coronary computed tomography. Subclinical atherosclerosis was defined as the presence of any plaque in carotid or femoral arteries and/or CACS =1. Logistic regression models were used to estimate the prevalence of atherosclerosis adjusted for risk factors and age, to evaluate the association of atherosclerosis with risk factors, and to calculate areas under the receiver-operating characteristic curves for the presence of positive CACS. 
Results: Subclinical atherosclerosis was found in 72% of participants. Plaques were most common in femoral arteries (54%), followed by coronary calcification (38%) and carotid plaques (34%). Association of atherosclerosis with risk factors was stronger in femoral arteries than carotid or coronary arteries. The area under the receiver-operating characteristic curve for prediction of positive CACS increased from 0.665 when considering only risk factors (dyslipidemia, current smoking, hypertension, diabetes, and age) to 0.719 when adding femoral and carotid plaques (p < 0.001). In this model, the femoral odds ratio (2.58) exceeded the carotid odds ratio (1.80) for prediction of positive CACS. 
Conclusions: Subclinical atherosclerosis was highly prevalent in this middle-aged male cohort. Association with risk factors and positive CACS was stronger in femoral than carotid arteries. Screening for femoral plaques may be an appealing strategy for improving cardiovascular risk scales and predicting coronary disease.
000131451 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000131451 590__ $$a19.896$$b2016
000131451 591__ $$aCARDIAC & CARDIOVASCULAR SYSTEMS$$b1 / 126 = 0.008$$c2016$$dQ1$$eT1
000131451 592__ $$a12.02$$b2016
000131451 593__ $$aCardiology and Cardiovascular Medicine$$c2016$$dQ1
000131451 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000131451 700__ $$0(orcid)0000-0002-9887-2629$$aCasasnovas, J. A.$$uUniversidad de Zaragoza
000131451 700__ $$aFernández-Ortiz, A.
000131451 700__ $$aFuster, V.
000131451 700__ $$aLeón-Latre, M.
000131451 700__ $$aJiménez-Borreguero, L. J.
000131451 700__ $$0(orcid)0000-0001-8807-9187$$aPocovi, M.$$uUniversidad de Zaragoza
000131451 700__ $$aHurtado-Roca, Y.
000131451 700__ $$aOrdovas, J. M.
000131451 700__ $$0(orcid)0000-0001-9142-0737$$aJarauta, E.$$uUniversidad de Zaragoza
000131451 700__ $$aGuallar, E.
000131451 700__ $$aIbañez, B.
000131451 700__ $$0(orcid)0000-0001-7043-0952$$aCiveira, F.$$uUniversidad de Zaragoza
000131451 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000131451 7102_ $$11002$$2060$$aUniversidad de Zaragoza$$bDpto. Bioq.Biolog.Mol. Celular$$cÁrea Bioquímica y Biolog.Mole.
000131451 773__ $$g67, 11 (2016), 1263-1274$$pJ. Am. Coll. Cardiol.$$tJOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY$$x0735-1097
000131451 8564_ $$s858414$$uhttps://zaguan.unizar.es/record/131451/files/texto_completo.pdf$$yPostprint
000131451 8564_ $$s2232970$$uhttps://zaguan.unizar.es/record/131451/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000131451 909CO $$ooai:zaguan.unizar.es:131451$$particulos$$pdriver
000131451 951__ $$a2024-02-09-14:29:35
000131451 980__ $$aARTICLE