doi:10.22489/CinC.2023.408engGómez Fonseca, NeurysRamírez, JuliaMartin-Yebra, AlbaM. Demidova, MarinaPlatonov, PyotrMartínez, Juan PabloLaguna, PabloChanges in T-peak-to-T-end Morphology Measured by Time-Warping Are Associated with Ischemia-Induced Ventricular Fibrillation in a Porcine ModelART-2023-136867In this work, we use a time-warping-based morphology variation index, dw , computed between the peak and the end of the T-wave, and assess its association with the occurrence of ventricular fibrillation (VF) episodes in ischemic conditions. ECG recordings from 26 pigs under- going a 40-minute coronary occlusion were analyzed. The dw series was obtained by quantifying the morphological differences between the final part of the T wave at different stages of the occlusion and a reference T wave in the control recording. During control recordings, dw remained stationary with a median value along each recording of 1.76 ms, IQR of 1.80, while during artery occlusion followed a well-marked gradual increasing trend as ischemia progressed, with median of 15.47 ms, IQR of 18.53. At the 20-to-25 min period from occlusion onset (and during 5 min prior to VF episode) d w averages in the VF group was significantly higher than in the non-VF group with median values of 40.0 (and 34.4) vs 7.8 (and 7.7) ms, with p-values of 0.002 (and 0.001), respectively. In conclusion, dynamic increases of the dw index during ischaemia progression in pigs are associated with VF occurrence.2023http://zaguan.unizar.es/record/13145210.22489/CinC.2023.408http://zaguan.unizar.es/record/131452oai:zaguan.unizar.es:131452info:eu-repo/grantAgreement/ES/AEI/PID2021-128972OA-I00info:eu-repo/grantAgreement/ES/DGA-FSE/T39-20Rinfo:eu-repo/grantAgreement/ES/DGA/LMP141-21info:eu-repo/grantAgreement/ES/MICINN/PID2019-104881RB-I00info:eu-repo/grantAgreement/ES/MICINN/PID2019-105674RB-I00info:eu-repo/grantAgreement/ES/MICINN/RYC2021-031413-Iinfo:eu-repo/grantAgreement/EUR/MICINN/TED2021-130459B-I00Computing in Cardiology 50 (2023), [4 pp.]All rights reservedhttp://www.europeana.eu/rights/rr-f/info:eu-repo/semantics/openAccess