000131464 001__ 131464
000131464 005__ 20250520101729.0
000131464 0247_ $$2doi$$a10.1021/jm501090m
000131464 0248_ $$2sideral$$a136777
000131464 037__ $$aART-2014-136777
000131464 041__ $$aeng
000131464 100__ $$aGarcía, Ana M.
000131464 245__ $$aModulation of cAMP-Specific PDE without Emetogenic Activity: New Sulfide-Like PDE7 Inhibitors
000131464 260__ $$c2014
000131464 5203_ $$aA forward chemical genetic approach was followed to discover new targets and lead compounds for Parkinson’s disease (PD) treatment. By analysis of the cell protection produced by some small molecules, a diphenyl sulfide compound was revealed to be a new phosphodiesterase 7 (PDE7) inhibitor and identified as a new hit. This result allows us to confirm the utility of PDE7 inhibitors as a potential pharmacological treatment of PD. On the basis of these data, a diverse family of diphenyl sulfides has been developed and pharmacologically evaluated in the present work. Moreover, to gain insight into the safety of PDE7 inhibitors for human chronic treatment, we evaluated the new compounds in a surrogate emesis model, showing nonemetic effects.
000131464 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000131464 590__ $$a5.447$$b2014
000131464 591__ $$aCHEMISTRY, MEDICINAL$$b3 / 59 = 0.051$$c2014$$dQ1$$eT1
000131464 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000131464 700__ $$aBrea, José
000131464 700__ $$aMorales-García, Jose A.
000131464 700__ $$aPerez, Daniel I.
000131464 700__ $$aGonzález, Alejandro
000131464 700__ $$aAlonso-Gil, Sandra
000131464 700__ $$0(orcid)0000-0003-1028-8581$$aGracia-Rubio, Irene
000131464 700__ $$aRos-Simó, Clara
000131464 700__ $$aConde, Santiago
000131464 700__ $$aCadavid, María Isabel
000131464 700__ $$aLoza, María Isabel
000131464 700__ $$aPerez-Castillo, Ana
000131464 700__ $$aValverde, Olga
000131464 700__ $$aMartinez, Ana
000131464 700__ $$aGil, Carmen
000131464 773__ $$g57, 20 (2014), 8590-8607$$pJ. med. chem.$$tJournal of medicinal chemistry$$x0022-2623
000131464 8564_ $$s5058683$$uhttps://zaguan.unizar.es/record/131464/files/texto_completo.pdf$$yVersión publicada
000131464 8564_ $$s3015026$$uhttps://zaguan.unizar.es/record/131464/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000131464 909CO $$ooai:zaguan.unizar.es:131464$$particulos$$pdriver
000131464 951__ $$a2025-05-20-10:14:02
000131464 980__ $$aARTICLE