131492 20241125101156.0 doi 10.1038/s41598-023-43287-4 sideral 136836 ART-2023-136836 eng Jonaitis, Paulius Comparison of the management of Helicobacter pylori infection between the older and younger European populations 2023 Access copy available to the general public Unrestricted The prevalence of Helicobacter pylori remains high in the older population. Specific age-related peculiarities may impact the outcomes of H. pylori treatment. The aim of the study was to evaluate the diagnostics and effectiveness of H. pylori eradication between the younger and older European populations. “European Registry on H. pylori Management (Hp-EuReg)” data from 2013 to 2022 were analyzed. Patients were divided into older (≥ 60 years) and younger (18–59 years) groups. Modified intention-to-treat (mITT) and per-protocol (PP) analysis was performed. 49,461 patients included of which 14,467 (29%) were older-aged. Concomitant medications and penicillin allergy were more frequent among the older patients. Differences between younger and older populations were observed in treatment duration in first-line treatment and in proton pump inhibitors (PPIs) doses in second-line treatment. The overall incidence of adverse events was lower in the older adults group. The overall first-line treatment mITT effectiveness was 88% in younger and 90% in the older patients (p < 0.05). The overall second-line mITT treatment effectiveness was 84% in both groups. The effectiveness of the most frequent first- and second-line triple therapies was suboptimal (< 90%) in both groups. Optimal efficacy (≥ 90%) was achieved by using bismuth and non-bismuth-based quadruple therapies. In conclusion, the approach to the diagnostics and treatment of H. pylori infection did not generally differ between younger and older patients. Main differences were reported in the concurrent medications, allergy to penicillin and adverse events both in first- and second-line treatment. Optimal effectiveness rates were mostly achieved by using bismuth and non-bismuth-based quadruple therapies. No clinically relevant differences in the effectiveness between the age groups were observed. info:eu-repo/grantAgreement/EC/HORIZON EUROPE/101095359/EU/An Artificially Intelligent Diagnostic Assistant for gastric inflammation/AIDA info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 3.8 2023 MULTIDISCIPLINARY SCIENCES 25 / 134 = 0.187 2023 Q1 T1 0.9 2023 Multidisciplinary 2023 Q1 7.5 2023 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Nyssen, Olga P. Saracino, Ilaria Maria Fiorini, Giulia Vaira, Dino Pérez-Aísa, Ángeles Tepes, Bojan Castro-Fernandez, Manuel Pabón-Carrasco, Manuel Keco-Huerga, Alma Voynovan, Irina Lucendo, Alfredo J. Lanas, Ángel Universidad de Zaragoza (orcid)0000-0001-5932-2889 Martínez Domínguez, Samuel J. Universidad de Zaragoza Alfaro Almajano, Enrique Universidad de Zaragoza Rodrigo, Luis Vologzanina, Ludmila Brglez Jurecic, Natasa Denkovski, Maja Bujanda, Luis Mahmudov, Umud Leja, Marcis Lerang, Frode Babayeva, Gülüstan Bordin, Dmitry S. Gasbarrini, Antonio Kupcinskas, Juozas Gridnyev, Oleksiy Rokkas, Theodore Marcos-Pinto, Ricardo Phull, Perminder S. Smith, Sinead M. Tonkic, Ante Boltin, Doron Buzás, György Miklós Šembera, Štepán Simsek, Halis Matysiak-Budnik, Tamara Milivojevic, Vladimir Marlicz, Wojciech Venerito, Marino Boyanova, Lyudmila Doulberis, Michael Capelle, Lisette G. Cano-Català, Anna Moreira, Leticia Mégraud, Francis O’Morain, Colm Gisbert, Javier P. Jonaitis, Laimas Bumane, Renate Mammadov, Emin Abdulkhakov, Rustam A. Fadeenko, Galina Huguet, Jose M. 1007 610 Universidad de Zaragoza Dpto. Medicina, Psiqu. y Derm. Area Medicina 13 (2023), 17235 [13 pp.] Sci. rep. (Nat. Publ. Group) Scientific reports (Nature Publishing Group) 2045-2322 2309751 http://zaguan.unizar.es/record/131492/files/texto_completo.pdf Versión publicada 2485332 http://zaguan.unizar.es/record/131492/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:131492 articulos driver 2024-11-22-12:09:08 ARTICLE