000131526 001__ 131526
000131526 005__ 20240212142201.0
000131526 0247_ $$2doi$$a10.1016/j.numecd.2011.01.010
000131526 0248_ $$2sideral$$a79091
000131526 037__ $$aART-2012-79091
000131526 041__ $$aeng
000131526 100__ $$0(orcid)0000-0002-5407-3876$$aSanclemente, T.$$uUniversidad de Zaragoza
000131526 245__ $$aNaturally-occurring phytosterols in the usual diet influence cholesterol metabolism in healthy subjects
000131526 260__ $$c2012
000131526 5203_ $$aBackground and aims
Modulation of cholesterol absorption is potentially an effective way of lowering blood cholesterol levels and decreasing inherent cardiovascular risk in the general population. It is well established that cholesterol absorption efficiency can be modified by the intake of foods enriched with gram-doses of phytosterols, but little is known about the effects of phytosterols in the usual diet, even though moderate doses have been reported to affect whole-body cholesterol metabolism. A way to indirectly measure cholesterol synthesis and absorption rates is by quantification of serum non-cholesterol sterols. The aim of this study was to investigate the role of naturally occurring phytosterol intake on cholesterol absorption and serum cholesterol concentrations in a Spanish free-living population.
Methods and results
A total of 85 healthy volunteers were studied regarding their dietary habits (using a validated food frequency questionnaire), lipid profile and surrogate markers of cholesterol metabolism. Subjects were classified into tertiles of total phytosterol intake, and differences in lipid profile and markers of cholesterol metabolism were assessed by multivariate linear regression models adjusted for various confounders. The estimated daily intake of phytosterols and cholesterol was 489 (median) and 513 (mean) mg, respectively. Both serum low-density lipoprotein (LDL)-cholesterol concentration and sitosterol-to-cholesterol ratio adjusted by sitosterol intake (a surrogate marker of intestinal cholesterol absorption) decreased significantly (p < 0.05, both) across tertiles of phytosterol intake.
Conclusion
Moderate doses of phytosterols in the habitual diet might have a protective effect on the lipid profile via decreasing cholesterol absorption.
000131526 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000131526 590__ $$a3.978$$b2012
000131526 591__ $$aCARDIAC & CARDIOVASCULAR SYSTEMS$$b29 / 122 = 0.238$$c2012$$dQ1$$eT1
000131526 591__ $$aNUTRITION & DIETETICS$$b11 / 75 = 0.147$$c2012$$dQ1$$eT1
000131526 591__ $$aENDOCRINOLOGY & METABOLISM$$b37 / 122 = 0.303$$c2012$$dQ2$$eT1
000131526 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000131526 700__ $$0(orcid)0000-0001-6952-5655$$aMarques-Lopes, I.$$uUniversidad de Zaragoza
000131526 700__ $$0(orcid)0000-0001-6364-1188$$aFajó-Pascual, M.$$uUniversidad de Zaragoza
000131526 700__ $$aCofán, M.
000131526 700__ $$0(orcid)0000-0001-9142-0737$$aJarauta, E.$$uUniversidad de Zaragoza
000131526 700__ $$aRos, E.
000131526 700__ $$0(orcid)0000-0002-1309-4363$$aPuzo, J.$$uUniversidad de Zaragoza
000131526 700__ $$aGarcía-Otín, A. L.
000131526 7102_ $$12008$$2640$$aUniversidad de Zaragoza$$bDpto. Produc.Animal Cienc.Ali.$$cÁrea Nutrición Bromatología
000131526 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000131526 7102_ $$11008$$2615$$aUniversidad de Zaragoza$$bDpto. Microb.Med.Pr.,Sal.Públ.$$cÁrea Medic.Prevent.Salud Públ.
000131526 773__ $$g22, 10 (2012), 849-855$$pNMCD, Nutr. Metab. Cardiovasc. Dis.$$tNutrition, Metabolism and Cardiovascular Diseases$$x0939-4753
000131526 8564_ $$s144696$$uhttps://zaguan.unizar.es/record/131526/files/texto_completo.pdf$$yPostprint
000131526 8564_ $$s1019740$$uhttps://zaguan.unizar.es/record/131526/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000131526 909CO $$ooai:zaguan.unizar.es:131526$$particulos$$pdriver
000131526 951__ $$a2024-02-12-13:53:41
000131526 980__ $$aARTICLE