000131530 001__ 131530
000131530 005__ 20240212142201.0
000131530 0247_ $$2doi$$a10.1053/j.gastro.2017.10.049
000131530 0248_ $$2sideral$$a104937
000131530 037__ $$aART-2018-104937
000131530 041__ $$aeng
000131530 100__ $$aBjarnason, I.
000131530 245__ $$aMechanisms of Damage to the Gastrointestinal Tract From Nonsteroidal Anti-Inflammatory Drugs
000131530 260__ $$c2018
000131530 5203_ $$aNonsteroidal anti-inflammatory drugs (NSAIDs) can damage the gastrointestinal tract, causing widespread morbidity and mortality. Although mechanisms of damage involve the activities of prostaglandin-endoperoxide synthase 1 (PTGS1 or cyclooxygenase [COX] 1) and PTGS1 (COX2), other factors are involved. We review the mechanisms of gastrointestinal damage induction by NSAIDs via COX-mediated and COX-independent processes. NSAIDs interact with phospholipids and uncouple mitochondrial oxidative phosphorylation, which initiates biochemical changes that impair function of the gastrointestinal barrier. The resulting increase in intestinal permeability leads to low-grade inflammation. NSAID inhibition of COX enzymes, along with luminal aggressors, results in erosions and ulcers, with potential complications of bleeding, protein loss, stricture formation, and perforation. We propose a model for NSAID-induced damage to the gastrointestinal tract that includes these complex, interacting, and inter-dependent factors. This model highlights the obstacles for the development of safer NSAIDs.
000131530 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000131530 590__ $$a19.233$$b2018
000131530 591__ $$aGASTROENTEROLOGY & HEPATOLOGY$$b2 / 84 = 0.024$$c2018$$dQ1$$eT1
000131530 592__ $$a7.384$$b2018
000131530 593__ $$aHepatology$$c2018$$dQ1
000131530 593__ $$aGastroenterology$$c2018$$dQ1
000131530 655_4 $$ainfo:eu-repo/semantics/review$$vinfo:eu-repo/semantics/publishedVersion
000131530 700__ $$aScarpignato, C.
000131530 700__ $$aHolmgren, E.
000131530 700__ $$aOlszewski, M.
000131530 700__ $$aRainsford, K.D.
000131530 700__ $$0(orcid)0000-0001-5932-2889$$aLanas, A.$$uUniversidad de Zaragoza
000131530 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000131530 773__ $$g154, 3 (2018), 500-514$$pGastroenterology$$tGastroenterology$$x0016-5085
000131530 8564_ $$s1810252$$uhttps://zaguan.unizar.es/record/131530/files/texto_completo.pdf$$yVersión publicada
000131530 8564_ $$s3207613$$uhttps://zaguan.unizar.es/record/131530/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000131530 909CO $$ooai:zaguan.unizar.es:131530$$particulos$$pdriver
000131530 951__ $$a2024-02-12-13:53:56
000131530 980__ $$aARTICLE