000131546 001__ 131546
000131546 005__ 20240219135521.0
000131546 0247_ $$2doi$$a10.1016/j.carbpol.2021.118543
000131546 0248_ $$2sideral$$a126019
000131546 037__ $$aART-2021-126019
000131546 041__ $$aeng
000131546 100__ $$0(orcid)0000-0002-1407-5922$$aArauzo, Beatriz$$uUniversidad de Zaragoza
000131546 245__ $$aDry powder formulation for pulmonary infections: Ciprofloxacin loaded in chitosan sub-micron particles generated by electrospray
000131546 260__ $$c2021
000131546 5060_ $$aAccess copy available to the general public$$fUnrestricted
000131546 5203_ $$aElectrospray was used as a one-step technique to generate inhalable ciprofloxacin-loaded chitosan sub-micron particles with potential use in the treatment of pulmonary infections. The effect of operating parameters was studied and the preparation method optimized. The final sizes of ciprofloxacin-loaded particles were 386.1 +/- 248.5 nm and 501.1 +/- 276.3 nm for high and low molecular weight chitosan, respectively. The high surface charge of the particles formed, around +45 mV, enhances their mucoadhesive properties. The particles were biocompatible with alveolar cell line (A549), and showed a high antimicrobial activity against two of the most common respiratory pathogens Staphylococcus aureus and Pseudomonas aeruginosa.
000131546 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII/CIBER-BBN
000131546 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000131546 590__ $$a10.723$$b2021
000131546 591__ $$aCHEMISTRY, APPLIED$$b4 / 72 = 0.056$$c2021$$dQ1$$eT1
000131546 591__ $$aPOLYMER SCIENCE$$b3 / 90 = 0.033$$c2021$$dQ1$$eT1
000131546 591__ $$aCHEMISTRY, ORGANIC$$b2 / 56 = 0.036$$c2021$$dQ1$$eT1
000131546 592__ $$a1.612$$b2021
000131546 593__ $$aOrganic Chemistry$$c2021$$dQ1
000131546 593__ $$aMaterials Chemistry$$c2021$$dQ1
000131546 594__ $$a16.0$$b2021
000131546 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000131546 700__ $$0(orcid)0000-0002-2436-1041$$aLobera, M. Pilar$$uUniversidad de Zaragoza
000131546 700__ $$0(orcid)0000-0002-7836-5777$$aMonzon, Antonio$$uUniversidad de Zaragoza
000131546 700__ $$0(orcid)0000-0002-8701-9745$$aSantamaria, Jesús$$uUniversidad de Zaragoza
000131546 7102_ $$15005$$2555$$aUniversidad de Zaragoza$$bDpto. Ing.Quím.Tecnol.Med.Amb.$$cÁrea Ingeniería Química
000131546 773__ $$g273 (2021), 118543 [8 pp.]$$pCarbohydr. polym.$$tCARBOHYDRATE POLYMERS$$x0144-8617
000131546 8564_ $$s1060598$$uhttps://zaguan.unizar.es/record/131546/files/texto_completo.pdf$$yPostprint
000131546 8564_ $$s1209850$$uhttps://zaguan.unizar.es/record/131546/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000131546 909CO $$ooai:zaguan.unizar.es:131546$$particulos$$pdriver
000131546 951__ $$a2024-02-19-13:51:50
000131546 980__ $$aARTICLE