doi:10.1016/j.carbpol.2021.118543engArauzo, BeatrizLobera, M. PilarMonzon, AntonioSantamaria, JesúsDry powder formulation for pulmonary infections: Ciprofloxacin loaded in chitosan sub-micron particles generated by electrosprayART-2021-126019Electrospray was used as a one-step technique to generate inhalable ciprofloxacin-loaded chitosan sub-micron particles with potential use in the treatment of pulmonary infections. The effect of operating parameters was studied and the preparation method optimized. The final sizes of ciprofloxacin-loaded particles were 386.1 +/- 248.5 nm and 501.1 +/- 276.3 nm for high and low molecular weight chitosan, respectively. The high surface charge of the particles formed, around +45 mV, enhances their mucoadhesive properties. The particles were biocompatible with alveolar cell line (A549), and showed a high antimicrobial activity against two of the most common respiratory pathogens Staphylococcus aureus and Pseudomonas aeruginosa.2021http://zaguan.unizar.es/record/13154610.1016/j.carbpol.2021.118543http://zaguan.unizar.es/record/131546oai:zaguan.unizar.es:131546info:eu-repo/grantAgreement/ES/ISCIII/CIBER-BBNCARBOHYDRATE POLYMERS 273 (2021), 118543 [8 pp.]by-nc-ndhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/info:eu-repo/semantics/openAccess