131546 20240219135521.0 doi 10.1016/j.carbpol.2021.118543 sideral 126019 ART-2021-126019 eng Arauzo, Beatriz Universidad de Zaragoza (orcid)0000-0002-1407-5922 Dry powder formulation for pulmonary infections: Ciprofloxacin loaded in chitosan sub-micron particles generated by electrospray 2021 Access copy available to the general public Unrestricted Electrospray was used as a one-step technique to generate inhalable ciprofloxacin-loaded chitosan sub-micron particles with potential use in the treatment of pulmonary infections. The effect of operating parameters was studied and the preparation method optimized. The final sizes of ciprofloxacin-loaded particles were 386.1 +/- 248.5 nm and 501.1 +/- 276.3 nm for high and low molecular weight chitosan, respectively. The high surface charge of the particles formed, around +45 mV, enhances their mucoadhesive properties. The particles were biocompatible with alveolar cell line (A549), and showed a high antimicrobial activity against two of the most common respiratory pathogens Staphylococcus aureus and Pseudomonas aeruginosa. info:eu-repo/grantAgreement/ES/ISCIII/CIBER-BBN info:eu-repo/semantics/openAccess by-nc-nd http://creativecommons.org/licenses/by-nc-nd/3.0/es/ 10.723 2021 CHEMISTRY, APPLIED 4 / 72 = 0.056 2021 Q1 T1 POLYMER SCIENCE 3 / 90 = 0.033 2021 Q1 T1 CHEMISTRY, ORGANIC 2 / 56 = 0.036 2021 Q1 T1 1.612 2021 Organic Chemistry 2021 Q1 Materials Chemistry 2021 Q1 16.0 2021 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Lobera, M. Pilar Universidad de Zaragoza (orcid)0000-0002-2436-1041 Monzon, Antonio Universidad de Zaragoza (orcid)0000-0002-7836-5777 Santamaria, Jesús Universidad de Zaragoza (orcid)0000-0002-8701-9745 5005 555 Universidad de Zaragoza Dpto. Ing.Quím.Tecnol.Med.Amb. Área Ingeniería Química 273 (2021), 118543 [8 pp.] Carbohydr. polym. CARBOHYDRATE POLYMERS 0144-8617 1060598 http://zaguan.unizar.es/record/131546/files/texto_completo.pdf Postprint 1209850 http://zaguan.unizar.es/record/131546/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:131546 articulos driver 2024-02-19-13:51:50 ARTICLE