doi:10.1039/d3nj03186aengD’Arcy, KennethSchäfer, TimDe Franco, MicheleRicco, RaffaeleGandin, ValentinaSanz Miguel, Pablo J.Montagner, DiegoUnusual tellurium(iv) mediated cyclisation diols into dihydroxazoles with potential anticancer activityART-2023-136921The role of tellurium in medicinal chemistry has recently grown in importance due to the discovery of the anticancer properties of SAS and AS-101, two inorganic compounds based on Te(IV). Here we describe an unprecedented isolation of a series of tetramethyl-dihydroxazole tellurium hexachloride salts whose structure has been indentified and characterised with several techniques including X-ray crystallography. The novelty resides on the role of tellurium that mediate the cyclisation of 1,1,2,2-tetramethylethylene into duhydroxazole in the presence of nitriles. Reaction mechanism, physiological stability and preliminary cytotoxicity results are discussed.2023http://zaguan.unizar.es/record/13159810.1039/d3nj03186ahttp://zaguan.unizar.es/record/131598oai:zaguan.unizar.es:131598info:eu-repo/grantAgreement/ES/DGA/E42-23Rinfo:eu-repo/grantAgreement/ES/MCIU-AEI-FEDER/PID2021-122406NB-I00NEW JOURNAL OF CHEMISTRY 47, 39 (2023), 18485-18491All rights reservedhttp://www.europeana.eu/rights/rr-f/info:eu-repo/semantics/closedAccess