131598 20250210083428.0 doi 10.1039/d3nj03186a sideral 136921 ART-2023-136921 eng D’Arcy, Kenneth Unusual tellurium(iv) mediated cyclisation diols into dihydroxazoles with potential anticancer activity 2023 The role of tellurium in medicinal chemistry has recently grown in importance due to the discovery of the anticancer properties of SAS and AS-101, two inorganic compounds based on Te(IV). Here we describe an unprecedented isolation of a series of tetramethyl-dihydroxazole tellurium hexachloride salts whose structure has been indentified and characterised with several techniques including X-ray crystallography. The novelty resides on the role of tellurium that mediate the cyclisation of 1,1,2,2-tetramethylethylene into duhydroxazole in the presence of nitriles. Reaction mechanism, physiological stability and preliminary cytotoxicity results are discussed. info:eu-repo/grantAgreement/ES/DGA/E42-23R info:eu-repo/grantAgreement/ES/MCIU-AEI-FEDER/PID2021-122406NB-I00 info:eu-repo/semantics/closedAccess All rights reserved http://www.europeana.eu/rights/rr-f/ 2.7 2023 CHEMISTRY, MULTIDISCIPLINARY 111 / 231 = 0.481 2023 Q2 T2 0.521 2023 Chemistry (miscellaneous) 2023 Q2 Materials Chemistry 2023 Q2 Catalysis 2023 Q3 5.3 2023 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Schäfer, Tim De Franco, Michele Ricco, Raffaele Gandin, Valentina Sanz Miguel, Pablo J. Universidad de Zaragoza (orcid)0000-0002-8220-6031 Montagner, Diego 2010 760 Universidad de Zaragoza Dpto. Química Inorgánica Área Química Inorgánica 47, 39 (2023), 18485-18491 New j. chem. NEW JOURNAL OF CHEMISTRY 1144-0546 552689 http://zaguan.unizar.es/record/131598/files/texto_completo.pdf Postprint 1539998 http://zaguan.unizar.es/record/131598/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:131598 articulos driver 2025-02-10-08:31:25 ARTICLE