000131670 001__ 131670
000131670 005__ 20241125101141.0
000131670 0247_ $$2doi$$a10.1016/j.cej.2023.146679
000131670 0248_ $$2sideral$$a137197
000131670 037__ $$aART-2023-137197
000131670 041__ $$aeng
000131670 100__ $$aMiranda-Calderon, Laura$$uUniversidad de Zaragoza
000131670 245__ $$aCombinatorial wound dressings loaded with synergistic antibiotics in the treatment of chronic infected wounds
000131670 260__ $$c2023
000131670 5060_ $$aAccess copy available to the general public$$fUnrestricted
000131670 5203_ $$aAdvanced medicated wound dressings fabricated by electrospinning and electrospraying were prepared for the eradication of topical bacterial infections potentially applied in the management of infected acute and chronic non-healing wounds. Two different antibiotics (ciprofloxacin and rifampicin), with different aqueous solubilities and different mechanisms of antimicrobial action, were loaded within electrosprayed polymer microparticles and within electrospun nanofibers, respectively, to provide the resulting wound dressing with dually controlled antibiotic release kinetics. Due to the large surface area per volume ratio of the electrosprayed microparticles containing ciprofloxacin, an initial burst release was obtained. Simultaneously, the reduced surface area per volume ratio for the electrospun nanofibers together with the reduced aqueous solubility of rifampicin produced an extended rifampicin release over time. More importantly, a synergistic antimicrobial effect against Gram-positive and Gram-negative bacteria was observed when both antibiotics were combined. Biofilm formation prevention and the elimination of already formed mature bacterial biofilms were also successfully achieved using our advanced dressings. The lack of cytotoxicity of the advanced wound dressings here reported against eukaryotic cells at antimicrobial doses was also demonstrated using three different mammalian cell lines. Moreover, the advanced wound dressings successfully eliminated a Staphylococcus aureus mediated experimental infection in a chronic wound murine model showing their efficacy for the treatment of these complicated non-healing wounds. The strategy of advanced medicated wound dressings developed here may be used as a potential methodology for the fabrication of functional combinatorial materials that offer the ability to eradicate bacterial infections.
000131670 536__ $$9info:eu-repo/grantAgreement/ES/AEI/PDC2021-121105-I00$$9info:eu-repo/grantAgreement/ES/ISCIII/MS19-00092$$9info:eu-repo/grantAgreement/ES/MCINN/PRE2018-085769$$9info:eu-repo/grantAgreement/ES/MICINN/PID2020-113987RB-I00
000131670 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000131670 590__ $$a13.4$$b2023
000131670 592__ $$a2.852$$b2023
000131670 591__ $$aENGINEERING, ENVIRONMENTAL$$b3 / 81 = 0.037$$c2023$$dQ1$$eT1
000131670 591__ $$aENGINEERING, CHEMICAL$$b7 / 170 = 0.041$$c2023$$dQ1$$eT1
000131670 593__ $$aEnvironmental Chemistry$$c2023$$dQ1
000131670 593__ $$aIndustrial and Manufacturing Engineering$$c2023$$dQ1
000131670 593__ $$aChemistry (miscellaneous)$$c2023$$dQ1
000131670 593__ $$aChemical Engineering (miscellaneous)$$c2023$$dQ1
000131670 594__ $$a21.7$$b2023
000131670 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000131670 700__ $$0(orcid)0000-0002-1505-498X$$aYus, Cristina$$uUniversidad de Zaragoza
000131670 700__ $$aRemirez de Ganuza, Cristina$$uUniversidad de Zaragoza
000131670 700__ $$aPaesa, Monica$$uUniversidad de Zaragoza
000131670 700__ $$0(orcid)0000-0003-1599-8216$$aLanda, Guillermo$$uUniversidad de Zaragoza
000131670 700__ $$aTapia, Elena$$uUniversidad de Zaragoza
000131670 700__ $$aPérez, Estela$$uUniversidad de Zaragoza
000131670 700__ $$0(orcid)0000-0002-8133-2124$$aPerez, Marta$$uUniversidad de Zaragoza
000131670 700__ $$0(orcid)0000-0002-6873-5244$$aSebastian, Victor$$uUniversidad de Zaragoza
000131670 700__ $$0(orcid)0000-0002-2966-9088$$aIrusta, Silvia$$uUniversidad de Zaragoza
000131670 700__ $$0(orcid)0000-0003-2293-363X$$aMendoza, Gracia
000131670 700__ $$0(orcid)0000-0003-3165-0156$$aArruebo, Manuel$$uUniversidad de Zaragoza
000131670 7102_ $$11009$$2773$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Sanidad Animal
000131670 7102_ $$11001$$2025$$aUniversidad de Zaragoza$$bDpto. Anatom.,Embri.Genét.Ani.$$cÁrea Anatom.Anatom.Patológ.Com
000131670 7102_ $$15005$$2555$$aUniversidad de Zaragoza$$bDpto. Ing.Quím.Tecnol.Med.Amb.$$cÁrea Ingeniería Química
000131670 7102_ $$10$$2X$$aUniversidad de Zaragoza$$bServ.Gral. Apoyo Investigación$$cServicios. División Biomédica
000131670 7102_ $$15005$$2790$$aUniversidad de Zaragoza$$bDpto. Ing.Quím.Tecnol.Med.Amb.$$cÁrea Tecnologi. Medio Ambiente
000131670 773__ $$g476 (2023), 146679 [15 pp.]$$pChem. eng. j.$$tChemical Engineering Journal$$x1385-8947
000131670 8564_ $$s13287800$$uhttps://zaguan.unizar.es/record/131670/files/texto_completo.pdf$$yVersión publicada
000131670 8564_ $$s2383897$$uhttps://zaguan.unizar.es/record/131670/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000131670 909CO $$ooai:zaguan.unizar.es:131670$$particulos$$pdriver
000131670 951__ $$a2024-11-22-12:02:36
000131670 980__ $$aARTICLE