000131679 001__ 131679
000131679 005__ 20241125101200.0
000131679 0247_ $$2doi$$a10.1016/j.envint.2023.108161
000131679 0248_ $$2sideral$$a137233
000131679 037__ $$aART-2023-137233
000131679 041__ $$aeng
000131679 100__ $$aMuncke, Jane
000131679 245__ $$aA vision for safer food contact materials: Public health concerns as drivers for improved testing
000131679 260__ $$c2023
000131679 5060_ $$aAccess copy available to the general public$$fUnrestricted
000131679 5203_ $$aFood contact materials (FCMs) and food contact articles are ubiquitous in today’s globalized food system. Chemicals migrate from FCMs into foodstuffs, so called food contact chemicals (FCCs), but current regulatory requirements do not sufficiently protect public health from hazardous FCCs because only individual substances used to make FCMs are tested and mostly only for genotoxicity while endocrine disruption and other hazard properties are disregarded. Indeed, FCMs are a known source of a wide range of hazardous chemicals, and they likely contribute to highly prevalent non-communicable diseases. FCMs can also include non-intentionally added substances (NIAS), which often are unknown and therefore not subject to risk assessment. To address these important shortcomings, we outline how the safety of FCMs may be improved by (1) testing the overall migrate, including (unknown) NIAS, of finished food contact articles, and (2) expanding toxicological testing beyond genotoxicity to multiple endpoints associated with non-communicable diseases relevant to human health. To identify mechanistic endpoints for testing, we group chronic health outcomes associated with chemical exposure into Six Clusters of Disease (SCOD) and we propose that finished food contact articles should be tested for their impacts on these SCOD. Research should focus on developing robust, relevant, and sensitive in-vitro assays based on mechanistic information linked to the SCOD, e.g., through Adverse Outcome Pathways (AOPs) or Key Characteristics of Toxicants. Implementing this vision will improve prevention of chronic diseases that are associated with hazardous chemical exposures, including from FCMs.
000131679 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000131679 590__ $$a10.3$$b2023
000131679 592__ $$a3.015$$b2023
000131679 591__ $$aENVIRONMENTAL SCIENCES$$b21 / 358 = 0.059$$c2023$$dQ1$$eT1
000131679 593__ $$aEnvironmental Science (miscellaneous)$$c2023$$dQ1
000131679 594__ $$a21.9$$b2023
000131679 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000131679 700__ $$aAndersson, Anna-Maria
000131679 700__ $$aBackhaus, Thomas
000131679 700__ $$aBelcher, Scott M.
000131679 700__ $$aBoucher, Justin M.
000131679 700__ $$aCarney Almroth, Bethanie
000131679 700__ $$aCollins, Terrence J.
000131679 700__ $$aGeueke, Birgit
000131679 700__ $$aGroh, Ksenia J.
000131679 700__ $$aHeindel, Jerrold J.
000131679 700__ $$avon Hippel, Frank A.
000131679 700__ $$aLegler, Juliette
000131679 700__ $$aMaffini, Maricel V.
000131679 700__ $$aMartin, Olwenn V.
000131679 700__ $$aPeterson Myers, John
000131679 700__ $$aNadal, Angel
000131679 700__ $$0(orcid)0000-0003-2685-5739$$aNerin, Cristina$$uUniversidad de Zaragoza
000131679 700__ $$aSoto, Ana M.
000131679 700__ $$aTrasande, Leonardo
000131679 700__ $$aVandenberg, Laura N.
000131679 700__ $$aWagner, Martin
000131679 700__ $$aZimmermann, Lisa
000131679 700__ $$aThomas Zoeller, R.
000131679 700__ $$aScheringer, Martin
000131679 7102_ $$12009$$2750$$aUniversidad de Zaragoza$$bDpto. Química Analítica$$cÁrea Química Analítica
000131679 773__ $$g180 (2023), 108161 [18 pp.]$$pEnviron. int.$$tENVIRONMENT INTERNATIONAL$$x0160-4120
000131679 8564_ $$s3840157$$uhttps://zaguan.unizar.es/record/131679/files/texto_completo.pdf$$yVersión publicada
000131679 8564_ $$s2388949$$uhttps://zaguan.unizar.es/record/131679/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000131679 909CO $$ooai:zaguan.unizar.es:131679$$particulos$$pdriver
000131679 951__ $$a2024-11-22-12:11:09
000131679 980__ $$aARTICLE