131679 20241125101200.0 doi 10.1016/j.envint.2023.108161 sideral 137233 ART-2023-137233 eng Muncke, Jane A vision for safer food contact materials: Public health concerns as drivers for improved testing 2023 Access copy available to the general public Unrestricted Food contact materials (FCMs) and food contact articles are ubiquitous in today’s globalized food system. Chemicals migrate from FCMs into foodstuffs, so called food contact chemicals (FCCs), but current regulatory requirements do not sufficiently protect public health from hazardous FCCs because only individual substances used to make FCMs are tested and mostly only for genotoxicity while endocrine disruption and other hazard properties are disregarded. Indeed, FCMs are a known source of a wide range of hazardous chemicals, and they likely contribute to highly prevalent non-communicable diseases. FCMs can also include non-intentionally added substances (NIAS), which often are unknown and therefore not subject to risk assessment. To address these important shortcomings, we outline how the safety of FCMs may be improved by (1) testing the overall migrate, including (unknown) NIAS, of finished food contact articles, and (2) expanding toxicological testing beyond genotoxicity to multiple endpoints associated with non-communicable diseases relevant to human health. To identify mechanistic endpoints for testing, we group chronic health outcomes associated with chemical exposure into Six Clusters of Disease (SCOD) and we propose that finished food contact articles should be tested for their impacts on these SCOD. Research should focus on developing robust, relevant, and sensitive in-vitro assays based on mechanistic information linked to the SCOD, e.g., through Adverse Outcome Pathways (AOPs) or Key Characteristics of Toxicants. Implementing this vision will improve prevention of chronic diseases that are associated with hazardous chemical exposures, including from FCMs. info:eu-repo/semantics/openAccess by-nc-nd http://creativecommons.org/licenses/by-nc-nd/3.0/es/ 10.3 2023 ENVIRONMENTAL SCIENCES 21 / 358 = 0.059 2023 Q1 T1 3.015 2023 Environmental Science (miscellaneous) 2023 Q1 21.9 2023 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Andersson, Anna-Maria Backhaus, Thomas Belcher, Scott M. Boucher, Justin M. Carney Almroth, Bethanie Collins, Terrence J. Geueke, Birgit Groh, Ksenia J. Heindel, Jerrold J. von Hippel, Frank A. Legler, Juliette Maffini, Maricel V. Martin, Olwenn V. Peterson Myers, John Nadal, Angel Nerin, Cristina Universidad de Zaragoza (orcid)0000-0003-2685-5739 Soto, Ana M. Trasande, Leonardo Vandenberg, Laura N. Wagner, Martin Zimmermann, Lisa Thomas Zoeller, R. Scheringer, Martin 2009 750 Universidad de Zaragoza Dpto. Química Analítica Área Química Analítica 180 (2023), 108161 [18 pp.] Environ. int. ENVIRONMENT INTERNATIONAL 0160-4120 3840157 http://zaguan.unizar.es/record/131679/files/texto_completo.pdf Versión publicada 2388949 http://zaguan.unizar.es/record/131679/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:131679 articulos driver 2024-11-22-12:11:09 ARTICLE