000131697 001__ 131697 000131697 005__ 20241125101141.0 000131697 0247_ $$2doi$$a10.1016/j.jcv.2023.105578 000131697 0248_ $$2sideral$$a137162 000131697 037__ $$aART-2023-137162 000131697 041__ $$aeng 000131697 100__ $$ade Mendoza, Carmen 000131697 245__ $$aAdult T-cell leukemia/lymphoma in HTLV-1 non-endemic regions 000131697 260__ $$c2023 000131697 5203_ $$aBackground HTLV-1 infection is a neglected disease, despite producing neurological and lymphoproliferative severe illnesses and affect over 10 million people worldwide. Roughly 5% of HTLV-1 carriers develop Adult T-cell leukemia/lymphoma (ATLL), one of the most aggressive hematological malignancies. Methods A national HTLV-1 register exists since 1989 in Spain, a non-endemic country with a large migrant flow from Latin America and Equatorial Africa, where HTLV-1 is endemic. The main features of all patients diagnosed with ATLL in Spain up to date are reported. Results A total of 451 cases of HTLV-1 infection had been reported in Spain until the end of year 2022. ATLL had been diagnosed in 35 (7.8%). The current average incidence of ATLL in Spain is of two cases per year. Women represent 57% of ATLL patients. Mean age at diagnosis was 47 years-old. Roughly 57% were Latin Americans and 26% Africans. At diagnosis, the majority presented with acute or lymphoma clinical forms. Survival was shorter than one year in most of them. Mean HTLV-1 proviral load was significantly greater in ATLL patients than in asymptomatic HTLV-1 carriers (2,305 vs 104 copies/104 PBMC). HTLV-1 subtyping in 6 ATLL patients found the 1a transcontinental variant (n = 4) and the Japanese variant (n = 2). All ATLL patients were negative for HIV-1, did not develop HTLV-1-associated myelopathy and were not transplant recipients. Conclusion The rate of ATLL is very low in Spain and mostly associated to migrants from HTLV-1 endemic regions. Given the poor clinical outcome of ATLL, HTLV-1 testing should be performed at least once in all migrants coming from HTLV-1 endemic countries and in natives who have lived in or had sex partners from such regions. 000131697 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI21-1717 000131697 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/ 000131697 590__ $$a4.0$$b2023 000131697 592__ $$a1.344$$b2023 000131697 591__ $$aVIROLOGY$$b14 / 41 = 0.341$$c2023$$dQ2$$eT2 000131697 593__ $$aVirology$$c2023$$dQ1 000131697 593__ $$aInfectious Diseases$$c2023$$dQ1 000131697 594__ $$a22.7$$b2023 000131697 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000131697 700__ $$aRando, Ariadna 000131697 700__ $$aMiró, Elisenda 000131697 700__ $$aPena, María José 000131697 700__ $$aRodríguez-Avial, Iciar 000131697 700__ $$aOrtega, Diego$$uUniversidad de Zaragoza 000131697 700__ $$aGonzález-Praetorius, Alejandro 000131697 700__ $$aReina, Gabriel 000131697 700__ $$aPintos, Ilduara 000131697 700__ $$aPozuelo, María José 000131697 700__ $$aSoriano, Vicente 000131697 700__ $$aCalderón, E. 000131697 700__ $$aRodríguez-Iglesias, M. 000131697 700__ $$aMontiel, N. 000131697 700__ $$aTrujillo, T. 000131697 700__ $$aViciana, I. 000131697 700__ $$aCabezas, T. 000131697 700__ $$aLozano, A. 000131697 700__ $$aFernández-Fuertes, E. 000131697 700__ $$aFernández, J.M. 000131697 700__ $$aGarcía, F. 000131697 700__ $$0(orcid)0000-0001-5134-1006$$aBenito, R.$$uUniversidad de Zaragoza 000131697 700__ $$0(orcid)0000-0002-0036-6630$$aAlgarate, S.$$uUniversidad de Zaragoza 000131697 700__ $$aDucons, M. 000131697 700__ $$aRoc, L. 000131697 700__ $$aCifuentes, C. 000131697 700__ $$aFernández-Baca, V. 000131697 700__ $$aFernández-Montero, J.V 000131697 700__ $$aMaciá, MD. 000131697 700__ $$aHernández-Betancor, A. 000131697 700__ $$aMartín, A.M. 000131697 700__ $$aHernández, M. 000131697 700__ $$aLópez-Lirola, A.M. 000131697 700__ $$aGómez-Sirvent, J.L. 000131697 700__ $$aCopado, R. 000131697 700__ $$aCano, M.E. 000131697 700__ $$aRojo, S. 000131697 700__ $$aEirós, J.M. 000131697 700__ $$aRodríguez, M. 000131697 700__ $$aGómez-Hernando, C. 000131697 700__ $$aForce, L. 000131697 700__ $$aCebollero, A. 000131697 700__ $$aDelgado, J.F. 000131697 700__ $$aRodríguez, G. 000131697 700__ $$aFernández-Pereira, L. 000131697 700__ $$aAguilera, A. 000131697 700__ $$aPereira, S. 000131697 700__ $$aGarcía, J. 000131697 700__ $$aTrigo, M. 000131697 700__ $$aDiz, J. 000131697 700__ $$aGarcía-Campello, M. 000131697 700__ $$aCortizo, S. 000131697 700__ $$aPérez, S. 000131697 700__ $$aMorano, L. 000131697 700__ $$aArazamendi, M. 000131697 700__ $$aSalicio, Y. 000131697 700__ $$aUgalde, E. 000131697 700__ $$aNieto, M.C. 000131697 700__ $$aLiendo, P. 000131697 700__ $$aGoikoetxea, A.J. 000131697 700__ $$aOcete, M.D. 000131697 700__ $$aRamos, J.M. 000131697 700__ $$aEscribano, I. 000131697 700__ $$aSauleda, S. 000131697 700__ $$aPirón, M. 000131697 700__ $$aGonzález, R. 000131697 700__ $$aRichart, A. 000131697 700__ $$aBarea, L. 000131697 700__ $$aJiménez, A. 000131697 700__ $$aBlanco, L. 000131697 700__ $$aNavarro, L. 000131697 700__ $$aAyerdi, O. 000131697 700__ $$aBaza, B. 000131697 700__ $$aRodriguez, C. 000131697 700__ $$adel Romero, J. 000131697 700__ $$aGalar, A. 000131697 700__ $$aAldamiz, T. 000131697 700__ $$aValeiro, M. 000131697 700__ $$aPérez, L. 000131697 700__ $$aMartín-Carbonero, L. 000131697 700__ $$aFernández-Ruiz, M. 000131697 700__ $$aParra, P. 000131697 700__ $$aRedondo, N. 000131697 700__ $$aRuiz-Merlo, T. 000131697 700__ $$aBarreiro, P. 000131697 700__ $$aTreviño, A. 000131697 700__ $$aCorral, O. 000131697 700__ $$aMoreno-Torres, V. 000131697 700__ $$aCarrizo, P. 000131697 700__ $$aHuertas, A. 000131697 700__ $$aVargas-Núñez, J.A. 000131697 7102_ $$11011$$2630$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Microbiología 000131697 773__ $$g167 (2023), 105578 [5 pp.]$$pJ. clin. virol.$$tJOURNAL OF CLINICAL VIROLOGY$$x1386-6532 000131697 8564_ $$s387838$$uhttps://zaguan.unizar.es/record/131697/files/texto_completo.pdf$$yVersión publicada 000131697 8564_ $$s2148776$$uhttps://zaguan.unizar.es/record/131697/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000131697 909CO $$ooai:zaguan.unizar.es:131697$$particulos$$pdriver 000131697 951__ $$a2024-11-22-12:02:35 000131697 980__ $$aARTICLE