131697 20241125101141.0 doi 10.1016/j.jcv.2023.105578 sideral 137162 ART-2023-137162 eng de Mendoza, Carmen Adult T-cell leukemia/lymphoma in HTLV-1 non-endemic regions 2023 Background HTLV-1 infection is a neglected disease, despite producing neurological and lymphoproliferative severe illnesses and affect over 10 million people worldwide. Roughly 5% of HTLV-1 carriers develop Adult T-cell leukemia/lymphoma (ATLL), one of the most aggressive hematological malignancies. Methods A national HTLV-1 register exists since 1989 in Spain, a non-endemic country with a large migrant flow from Latin America and Equatorial Africa, where HTLV-1 is endemic. The main features of all patients diagnosed with ATLL in Spain up to date are reported. Results A total of 451 cases of HTLV-1 infection had been reported in Spain until the end of year 2022. ATLL had been diagnosed in 35 (7.8%). The current average incidence of ATLL in Spain is of two cases per year. Women represent 57% of ATLL patients. Mean age at diagnosis was 47 years-old. Roughly 57% were Latin Americans and 26% Africans. At diagnosis, the majority presented with acute or lymphoma clinical forms. Survival was shorter than one year in most of them. Mean HTLV-1 proviral load was significantly greater in ATLL patients than in asymptomatic HTLV-1 carriers (2,305 vs 104 copies/104 PBMC). HTLV-1 subtyping in 6 ATLL patients found the 1a transcontinental variant (n = 4) and the Japanese variant (n = 2). All ATLL patients were negative for HIV-1, did not develop HTLV-1-associated myelopathy and were not transplant recipients. Conclusion The rate of ATLL is very low in Spain and mostly associated to migrants from HTLV-1 endemic regions. Given the poor clinical outcome of ATLL, HTLV-1 testing should be performed at least once in all migrants coming from HTLV-1 endemic countries and in natives who have lived in or had sex partners from such regions. info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI21-1717 info:eu-repo/semantics/closedAccess All rights reserved http://www.europeana.eu/rights/rr-f/ 4.0 2023 VIROLOGY 14 / 41 = 0.341 2023 Q2 T2 1.344 2023 Virology 2023 Q1 Infectious Diseases 2023 Q1 22.7 2023 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Rando, Ariadna Miró, Elisenda Pena, María José Rodríguez-Avial, Iciar Ortega, Diego Universidad de Zaragoza González-Praetorius, Alejandro Reina, Gabriel Pintos, Ilduara Pozuelo, María José Soriano, Vicente Calderón, E. Rodríguez-Iglesias, M. Montiel, N. Trujillo, T. Viciana, I. Cabezas, T. Lozano, A. Fernández-Fuertes, E. Fernández, J.M. García, F. Benito, R. Universidad de Zaragoza (orcid)0000-0001-5134-1006 Algarate, S. Universidad de Zaragoza (orcid)0000-0002-0036-6630 Ducons, M. Roc, L. Cifuentes, C. Fernández-Baca, V. Fernández-Montero, J.V Maciá, MD. Hernández-Betancor, A. Martín, A.M. Hernández, M. López-Lirola, A.M. Gómez-Sirvent, J.L. Copado, R. Cano, M.E. Rojo, S. Eirós, J.M. Rodríguez, M. Gómez-Hernando, C. Force, L. Cebollero, A. Delgado, J.F. Rodríguez, G. Fernández-Pereira, L. Aguilera, A. Pereira, S. García, J. Trigo, M. Diz, J. García-Campello, M. Cortizo, S. Pérez, S. Morano, L. Arazamendi, M. Salicio, Y. Ugalde, E. Nieto, M.C. Liendo, P. Goikoetxea, A.J. Ocete, M.D. Ramos, J.M. Escribano, I. Sauleda, S. Pirón, M. González, R. Richart, A. Barea, L. Jiménez, A. Blanco, L. Navarro, L. Ayerdi, O. Baza, B. Rodriguez, C. del Romero, J. Galar, A. Aldamiz, T. Valeiro, M. Pérez, L. Martín-Carbonero, L. Fernández-Ruiz, M. Parra, P. Redondo, N. Ruiz-Merlo, T. Barreiro, P. Treviño, A. Corral, O. Moreno-Torres, V. Carrizo, P. Huertas, A. Vargas-Núñez, J.A. 1011 630 Universidad de Zaragoza Dpto. Microb.Ped.Radio.Sal.Pú. Área Microbiología 167 (2023), 105578 [5 pp.] J. clin. virol. JOURNAL OF CLINICAL VIROLOGY 1386-6532 387838 http://zaguan.unizar.es/record/131697/files/texto_completo.pdf Versión publicada 2148776 http://zaguan.unizar.es/record/131697/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:131697 articulos driver 2024-11-22-12:02:35 ARTICLE