000131703 001__ 131703 000131703 005__ 20240711085509.0 000131703 0247_ $$2doi$$a10.1093/infdis/jiad471 000131703 0248_ $$2sideral$$a137032 000131703 037__ $$aART-2024-137032 000131703 041__ $$aeng 000131703 100__ $$aJairoce, Chenjerai 000131703 245__ $$aRTS,S/AS02A Malaria Vaccine-Induced IgG Responses Equally Recognize Native-Like Fucosylated and Nonfucosylated <i>Plasmodium falciparum</i> Circumsporozoite Proteins 000131703 260__ $$c2024 000131703 5203_ $$aThe RTS,S/AS02A malaria vaccine is based on the Plasmodium falciparum circumsporozoite protein (PfCSP), which is O-fucosylated on the sporozoite surface. We determined whether RTS,S/AS02A-induced immunoglobulin G (IgG) antibodies recognize vaccine-like nonfucosylated PfCSP better than native-like fucosylated PfCSP. Similar to previous vaccine trials, RTS,S/AS02A vaccination induced high anti-PfCSP IgG levels associated with malaria protection. IgG recognition of nonfucosylated and fucosylated PfCSP was equivalent, suggesting that PfCSP fucosylation does not affect antibody recognition. 000131703 536__ $$9info:eu-repo/grantAgreement/ES/MICINN/PID2019-110810RB-I00/AEI/10.13039/501100011033$$9info:eu-repo/grantAgreement/ES/MICINN/RYC2020-029886-I/AEI/10.13039/501100011033 000131703 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/ 000131703 592__ $$a2.387$$b2023 000131703 593__ $$aInfectious Diseases$$c2023$$dQ1 000131703 593__ $$aImmunology and Allergy$$c2023$$dQ1 000131703 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000131703 700__ $$aMacià, Dídac 000131703 700__ $$aTorres-Yaguana, Jorge P 000131703 700__ $$aMayer, Leonie 000131703 700__ $$aVidal, Marta 000131703 700__ $$aSantano, Rebeca 000131703 700__ $$0(orcid)0000-0002-3122-9401$$aHurtado-Guerrero, Ramón 000131703 700__ $$aReiter, Karine 000131703 700__ $$aNarum, David L 000131703 700__ $$aLopez-Gutierrez, Borja 000131703 700__ $$aHamerly, Timothy 000131703 700__ $$aSacarlal, Jahit 000131703 700__ $$aAguilar, Ruth 000131703 700__ $$aDinglasan, Rhoel R 000131703 700__ $$aMoncunill, Gemma 000131703 700__ $$aIzquierdo, Luis 000131703 700__ $$aDobaño, Carlota 000131703 773__ $$g229, 3 (2024), 795–799$$pJ. infect. dis.$$tJOURNAL OF INFECTIOUS DISEASES$$x0022-1899 000131703 8564_ $$s563128$$uhttps://zaguan.unizar.es/record/131703/files/texto_completo.pdf$$yVersión publicada 000131703 8564_ $$s3271071$$uhttps://zaguan.unizar.es/record/131703/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000131703 909CO $$ooai:zaguan.unizar.es:131703$$particulos$$pdriver 000131703 951__ $$a2024-07-11-08:52:10 000131703 980__ $$aARTICLE