000131708 001__ 131708
000131708 005__ 20241125101139.0
000131708 0247_ $$2doi$$a10.1212/WNL.0000000000203162
000131708 0248_ $$2sideral$$a136999
000131708 037__ $$aART-2023-136999
000131708 041__ $$aeng
000131708 100__ $$aSainz de la Maza, Susana
000131708 245__ $$aSymptom Severity in Early-stage Relapsing Remitting Multiple Sclerosis (P5-3.009)
000131708 260__ $$c2023
000131708 5203_ $$aObjective:
The aim of this study was to assess the illness perception and associated factors in early-stage relapsing remitting multiple sclerosis (RRMS) patients.
Background:
Patients with early-stage RRMS experience uncertainty and intense emotions as diagnosis is disclosed. Illness perception at this point can influence levels of adjustment, coping strategies, and patients’ well-being.
Design/Methods:
A multicentre, non-interventional study was conducted. Adult patients with RRMS, disease duration ≤3 years, and Expanded Disability Status Scale (EDSS) score between 0–5.5 were included. The Brief-Illness Perception Questionnaire (B-IPQ) was used to assess patients’ cognitive and emotional illness representation. Patient-reported measures were administered to gather information on different outcomes.
A multivariate logistic regression analysis was performed to assess the association between B-IPQ and demographic, clinical characteristics, and patients’ perspectives.
Results:
A total of 189 patients were included (mean age: 36.1±9.4 years, 71.4% female, mean disease duration: 1.4±0.8 years). Median EDSS score was 1.0 (IQR=0.0–2.0).
A proportion of 36.5% (n=69/189) patients had a moderate-to-high threatening illness perception, and 45.5% of patients thought that their MS was caused by psychological factors.
Bivariate analyses suggested that patients were significantly more likely to have a threatening disease perception if they were unemployed, received symptomatic treatment, had a higher EDSS, worse hand dexterity and gait, higher perception of pain, fatigue, symptom severity, hopelessness, and worse perception of their quality of life. Also patients that reported workplace barriers, cognitive complaints, and probable cases of anxiety, depression, and stigma.
Higher EDSS, symptom severity, worse psychological quality of life, perception of stigma, and higher hopelessness-trait were predictors of moderate-to-high threatening illness perception (OR=2.349, 95%CI:1.276–5.130; OR=1.208, 95%CI:1.089–1.364; OR=1.051, 95%CI:1.018–1.089; OR=3.365, 95%CI:1.152–10.796; OR=41.177, 95%CI:6.942–388.825, respectively, all p<0.05).
Conclusions:
Threatening illness perceptions are common among patients with early RRMS. Identifying these beliefs and its associated factors and establishing individualized interventions may help patients deal with their condition.
000131708 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000131708 590__ $$a8.4$$b2023
000131708 592__ $$a2.404$$b2023
000131708 591__ $$aCLINICAL NEUROLOGY$$b11 / 280 = 0.039$$c2023$$dQ1$$eT1
000131708 593__ $$aNeurology (clinical)$$c2023$$dQ1
000131708 594__ $$a12.2$$b2023
000131708 655_4 $$ainfo:eu-repo/semantics/conferenceObject$$vinfo:eu-repo/semantics/publishedVersion
000131708 700__ $$aGómez-Ballesteros, Rocío
000131708 700__ $$aBorges, Mónica
000131708 700__ $$aMartín-Martínez, Jesús
000131708 700__ $$aSotoca, Javier
000131708 700__ $$aAlonso, Ana
000131708 700__ $$aCaminero, Ana B.
000131708 700__ $$aBorrega, Laura
000131708 700__ $$aSánchez-Menoyo, José L.
000131708 700__ $$aBarrero-Hernández, Francisco J.
000131708 700__ $$aCalles, Carmen
000131708 700__ $$aBrieva, Luis
000131708 700__ $$aBlasco-Quílez, María R.
000131708 700__ $$aGarcia-Soto, Julio Dotor
000131708 700__ $$adel Campo-Amigo, María
000131708 700__ $$aNavarro-Cantó, Laura
000131708 700__ $$aAgüera, Eduardo
000131708 700__ $$0(orcid)0000-0002-1756-5492$$aGarcés-Redondo, Moisés$$uUniversidad de Zaragoza
000131708 700__ $$aCarmona, Olga
000131708 700__ $$aGabaldón-Torres, Laura
000131708 700__ $$aForero, Lucía
000131708 700__ $$aHervás, Mariona
000131708 700__ $$aMaurino, Jorge
000131708 700__ $$aCastillo-Trivino, Tamara
000131708 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000131708 773__ $$g100, 17, Suppl. 2 (2023), [5 pp.]$$pNeurology$$tNEUROLOGY$$x0028-3878
000131708 8564_ $$s2841980$$uhttps://zaguan.unizar.es/record/131708/files/texto_completo.pdf$$yVersión publicada
000131708 8564_ $$s1222329$$uhttps://zaguan.unizar.es/record/131708/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000131708 909CO $$ooai:zaguan.unizar.es:131708$$particulos$$pdriver
000131708 951__ $$a2024-11-22-12:01:53
000131708 980__ $$aARTICLE