131708 20241125101139.0 doi 10.1212/WNL.0000000000203162 sideral 136999 ART-2023-136999 eng Sainz de la Maza, Susana Symptom Severity in Early-stage Relapsing Remitting Multiple Sclerosis (P5-3.009) 2023 Objective: The aim of this study was to assess the illness perception and associated factors in early-stage relapsing remitting multiple sclerosis (RRMS) patients. Background: Patients with early-stage RRMS experience uncertainty and intense emotions as diagnosis is disclosed. Illness perception at this point can influence levels of adjustment, coping strategies, and patients’ well-being. Design/Methods: A multicentre, non-interventional study was conducted. Adult patients with RRMS, disease duration ≤3 years, and Expanded Disability Status Scale (EDSS) score between 0–5.5 were included. The Brief-Illness Perception Questionnaire (B-IPQ) was used to assess patients’ cognitive and emotional illness representation. Patient-reported measures were administered to gather information on different outcomes. A multivariate logistic regression analysis was performed to assess the association between B-IPQ and demographic, clinical characteristics, and patients’ perspectives. Results: A total of 189 patients were included (mean age: 36.1±9.4 years, 71.4% female, mean disease duration: 1.4±0.8 years). Median EDSS score was 1.0 (IQR=0.0–2.0). A proportion of 36.5% (n=69/189) patients had a moderate-to-high threatening illness perception, and 45.5% of patients thought that their MS was caused by psychological factors. Bivariate analyses suggested that patients were significantly more likely to have a threatening disease perception if they were unemployed, received symptomatic treatment, had a higher EDSS, worse hand dexterity and gait, higher perception of pain, fatigue, symptom severity, hopelessness, and worse perception of their quality of life. Also patients that reported workplace barriers, cognitive complaints, and probable cases of anxiety, depression, and stigma. Higher EDSS, symptom severity, worse psychological quality of life, perception of stigma, and higher hopelessness-trait were predictors of moderate-to-high threatening illness perception (OR=2.349, 95%CI:1.276–5.130; OR=1.208, 95%CI:1.089–1.364; OR=1.051, 95%CI:1.018–1.089; OR=3.365, 95%CI:1.152–10.796; OR=41.177, 95%CI:6.942–388.825, respectively, all p<0.05). Conclusions: Threatening illness perceptions are common among patients with early RRMS. Identifying these beliefs and its associated factors and establishing individualized interventions may help patients deal with their condition. info:eu-repo/semantics/closedAccess All rights reserved http://www.europeana.eu/rights/rr-f/ 8.4 2023 CLINICAL NEUROLOGY 11 / 280 = 0.039 2023 Q1 T1 2.404 2023 Neurology (clinical) 2023 Q1 12.2 2023 info:eu-repo/semantics/conferenceObject info:eu-repo/semantics/publishedVersion Gómez-Ballesteros, Rocío Borges, Mónica Martín-Martínez, Jesús Sotoca, Javier Alonso, Ana Caminero, Ana B. Borrega, Laura Sánchez-Menoyo, José L. Barrero-Hernández, Francisco J. Calles, Carmen Brieva, Luis Blasco-Quílez, María R. Garcia-Soto, Julio Dotor del Campo-Amigo, María Navarro-Cantó, Laura Agüera, Eduardo Garcés-Redondo, Moisés Universidad de Zaragoza (orcid)0000-0002-1756-5492 Carmona, Olga Gabaldón-Torres, Laura Forero, Lucía Hervás, Mariona Maurino, Jorge Castillo-Trivino, Tamara 1007 610 Universidad de Zaragoza Dpto. Medicina, Psiqu. y Derm. Area Medicina 100, 17, Suppl. 2 (2023), [5 pp.] Neurology NEUROLOGY 0028-3878 2841980 http://zaguan.unizar.es/record/131708/files/texto_completo.pdf Versión publicada 1222329 http://zaguan.unizar.es/record/131708/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:131708 articulos driver 2024-11-22-12:01:53 ARTICLE