doi:10.1002/adsc.202300563engMarqués-López, EugeniaGimeno Sonsona, IsaacGarcés-Marín, MiryamGimeno, M. ConcepciónPérez Herrera, RaquelAsymmetric organocatalyzed phospha-michael addition for the direct synthesis of biologically active chromenylphosphonatesART-2023-137051The potential of phosphites as nucleophiles for the asymmetric synthesis of chiral chromene derivatives has been overlooked in the literature. Herein, we report a promising approach via asymmetric organocatalyzed phospha‐Michael addition to iminochromenes, using a bifunctional squaramide, which gives access to chromenylphosphonates, an interesting family of bioactive compounds. Our optimized protocol provides very good reactivity, affording yields of up to 95% and with chiral products exhibiting an enantiomeric excess of up to 98%.2023http://zaguan.unizar.es/record/13172810.1002/adsc.202300563http://zaguan.unizar.es/record/131728oai:zaguan.unizar.es:131728info:eu-repo/grantAgreement/ES/AEI/PID2019-104379RB-C21info:eu-repo/grantAgreement/ES/AEI/PID2020-117455GB-I00info:eu-repo/grantAgreement/ES/DGA/E07-23RAdvanced Synthesis and Catalysis 365, 19 (2023), 3234-3240by-nc-ndhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/info:eu-repo/semantics/openAccess