000131794 001__ 131794 000131794 005__ 20241125101202.0 000131794 0247_ $$2doi$$a10.22319/rmcp.v14i4.6419 000131794 0248_ $$2sideral$$a137091 000131794 037__ $$aART-2023-137091 000131794 041__ $$aspa 000131794 100__ $$aRuíz-Ramírez, Johnatan Alberto 000131794 245__ $$aAdenocarcinoma pulmonar ovino en México 000131794 260__ $$c2023 000131794 5060_ $$aAccess copy available to the general public$$fUnrestricted 000131794 5203_ $$aOvine pulmonary adenocarcinoma is a transmissible pulmonary malignancy of sheep caused by a beta-retrovirus currently named Jaagsiekte sheep retrovirus (JSRV). Club cells (formerly Clara cells) in the bronchiole and type II pneumonocytes in the alveoli are the target oncogenic cells for this virus. Characterized clinically by intermittent cough, abundant nasal discharge, and progressive weight loss, the tumors randomly involve all lung lobes or have a cranioventral distribution mimicking bronchopneumonia. The definitive diagnosis of ovine pulmonary adenocarcinoma requires identifying Jaagsiekte sheep retrovirus or associated specific proteins in neoplastic cells such as JSRV-Env oncogenic protein. A two-year-old Male Pelibuey sheep with a history of chronic cough and progressive weight loss was treated unsuccessfully with antibiotics and died a few days later. Postmortem examination revealed lung edema and several nodular to locally extensive masses in the lungs. Microscopically the tumoral tissues were composed of clusters of neoplastic epithelial cells exhibiting a lepidic growth pattern typical of pulmonary carcinoma. Tumoral cells were immunopositive for Jaagsiekte sheep retrovirus-Env oncogenic protein. Based on these findings, the final diagnosis of ovine pulmonary adenocarcinoma was made. 000131794 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-sa$$uhttp://creativecommons.org/licenses/by-nc-sa/3.0/es/ 000131794 590__ $$a0.7$$b2023 000131794 592__ $$a0.235$$b2023 000131794 591__ $$aAGRICULTURE, DAIRY & ANIMAL SCIENCE$$b59 / 80 = 0.738$$c2023$$dQ3$$eT3 000131794 593__ $$aVeterinary (miscellaneous)$$c2023$$dQ3 000131794 593__ $$aAnimal Science and Zoology$$c2023$$dQ3 000131794 594__ $$a1.2$$b2023 000131794 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000131794 700__ $$aChávez-Ramírez, Brayan Jossue 000131794 700__ $$aGarcía-Valle, Jorge Luis 000131794 700__ $$0(orcid)0000-0003-3792-287X$$aDe las Heras, Marcelo$$uUniversidad de Zaragoza 000131794 700__ $$aLópez-Mayagoitia, Alfonso 000131794 700__ $$aGarcía-Márquez, Luis Jorge 000131794 7102_ $$11009$$2773$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Sanidad Animal 000131794 773__ $$g14, 4 (2023), 923-930$$pREVISTA MEXICANA DE CIENCIAS PECUARIAS$$tREVISTA MEXICANA DE CIENCIAS PECUARIAS$$x2007-1124 000131794 8564_ $$s667626$$uhttps://zaguan.unizar.es/record/131794/files/texto_completo.pdf$$yVersión publicada 000131794 8564_ $$s1451735$$uhttps://zaguan.unizar.es/record/131794/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000131794 909CO $$ooai:zaguan.unizar.es:131794$$particulos$$pdriver 000131794 951__ $$a2024-11-22-12:12:04 000131794 980__ $$aARTICLE