000131798 001__ 131798
000131798 005__ 20250923084417.0
000131798 0247_ $$2doi$$a10.1038/s41598-024-54099-5
000131798 0248_ $$2sideral$$a137037
000131798 037__ $$aART-2024-137037
000131798 041__ $$aeng
000131798 100__ $$aArias Álvarez, Marta
000131798 245__ $$aElectrophysiological findings in long-term type 1 diabetes patients without diabetic retinopathy using different ERG recording systems
000131798 260__ $$c2024
000131798 5203_ $$aTo assess full-field electroretinogram findings in long-term type 1 diabetes patients without diabetic retinopathy. Prospective study including 46 eyes of 23 patients with type 1 diabetes and 46 age-matched healthy eyes evaluated by the RETI-port/scan21 and the portable system RETeval following ISCEV guidelines. The average duration of diabetes was 28.88 ± 8.04 years. In scotopic conditions, using the RETI-port/scan21, diabetic patients showed an increase in b-wave implicit time (IT) (p = 0.017) with the lowest stimuli; a diminished b-wave amplitude (p = 0.005) in the mixed response, an increased IT (p = 0.004) with the high-intensity stimuli and an OP2 increased IT (p = 0.008) and decreased amplitude (p = 0.002). Under photopic conditions, b-wave amplitude was lower (p < 0.001) and 30-Hz flicker response was diminished (p = 0.021). Using the RETeval, in scotopic conditions, diabetic patients showed a reduction in the rod b-wave amplitude (p = 0.009), an increase in a-wave IT with the 280 Td.s stimulus (p = 0.005). OP2 had an increased IT and diminished amplitude (p = 0.003 and p = 0.002 respectively). 16 Td.s flicker showed an increased IT (p = 0.008) and diminished amplitude (p = 0.048). Despite variations in values between both systems, nearly all results displayed positive correlations. Long-term type 1 diabetes patients without diabetic retinopathy exhibit alterations in scotopic conditions, as evidenced by both conventional and portable electroretinogram devices. These findings suggest a modified retinal function, particularly in rod-driven pathways, even in the absence of vascular signs.
000131798 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI20-00740
000131798 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000131798 590__ $$a3.9$$b2024
000131798 592__ $$a0.874$$b2024
000131798 591__ $$aMULTIDISCIPLINARY SCIENCES$$b25 / 135 = 0.185$$c2024$$dQ1$$eT1
000131798 593__ $$aMultidisciplinary$$c2024$$dQ1
000131798 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000131798 700__ $$aTomas-Grasa, Cristina
000131798 700__ $$aSopeña-Pinilla, María
000131798 700__ $$0(orcid)0000-0003-2710-1875$$aOrduna-Hospital, Elvira$$uUniversidad de Zaragoza
000131798 700__ $$0(orcid)0000-0003-1234-9712$$aFernández-Espinosa, Guisela$$uUniversidad de Zaragoza
000131798 700__ $$aBielsa Alonso, Sofia
000131798 700__ $$0(orcid)0000-0002-2987-6351$$aAcha-Pérez, Javier
000131798 700__ $$aRodriguez-Mena, Diego$$uUniversidad de Zaragoza
000131798 700__ $$0(orcid)0000-0003-0349-9997$$aPinilla, Isabel$$uUniversidad de Zaragoza
000131798 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000131798 7102_ $$11013$$2646$$aUniversidad de Zaragoza$$bDpto. Cirugía$$cÁrea Oftalmología
000131798 7102_ $$12002$$2647$$aUniversidad de Zaragoza$$bDpto. Física Aplicada$$cÁrea Óptica
000131798 773__ $$g14, 3520 (2024), 1-13$$pSci. rep. (Nat. Publ. Group)$$tScientific reports (Nature Publishing Group)$$x2045-2322
000131798 8564_ $$s1262212$$uhttps://zaguan.unizar.es/record/131798/files/texto_completo.pdf$$yVersión publicada
000131798 8564_ $$s2426219$$uhttps://zaguan.unizar.es/record/131798/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000131798 909CO $$ooai:zaguan.unizar.es:131798$$particulos$$pdriver
000131798 951__ $$a2025-09-22-14:33:23
000131798 980__ $$aARTICLE