131798 20260217205505.0 doi 10.1038/s41598-024-54099-5 sideral 137037 ART-2024-137037 eng Arias Álvarez, Marta Electrophysiological findings in long-term type 1 diabetes patients without diabetic retinopathy using different ERG recording systems 2024 To assess full-field electroretinogram findings in long-term type 1 diabetes patients without diabetic retinopathy. Prospective study including 46 eyes of 23 patients with type 1 diabetes and 46 age-matched healthy eyes evaluated by the RETI-port/scan21 and the portable system RETeval following ISCEV guidelines. The average duration of diabetes was 28.88 ± 8.04 years. In scotopic conditions, using the RETI-port/scan21, diabetic patients showed an increase in b-wave implicit time (IT) (p = 0.017) with the lowest stimuli; a diminished b-wave amplitude (p = 0.005) in the mixed response, an increased IT (p = 0.004) with the high-intensity stimuli and an OP2 increased IT (p = 0.008) and decreased amplitude (p = 0.002). Under photopic conditions, b-wave amplitude was lower (p < 0.001) and 30-Hz flicker response was diminished (p = 0.021). Using the RETeval, in scotopic conditions, diabetic patients showed a reduction in the rod b-wave amplitude (p = 0.009), an increase in a-wave IT with the 280 Td.s stimulus (p = 0.005). OP2 had an increased IT and diminished amplitude (p = 0.003 and p = 0.002 respectively). 16 Td.s flicker showed an increased IT (p = 0.008) and diminished amplitude (p = 0.048). Despite variations in values between both systems, nearly all results displayed positive correlations. Long-term type 1 diabetes patients without diabetic retinopathy exhibit alterations in scotopic conditions, as evidenced by both conventional and portable electroretinogram devices. These findings suggest a modified retinal function, particularly in rod-driven pathways, even in the absence of vascular signs. info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI20-00740 info:eu-repo/semantics/closedAccess by https://creativecommons.org/licenses/by/4.0/deed.es 3.9 2024 MULTIDISCIPLINARY SCIENCES 25 / 136 = 0.184 2024 Q1 T1 0.874 2024 Multidisciplinary 2024 Q1 6.7 2024 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Tomas-Grasa, Cristina Sopeña-Pinilla, María Orduna-Hospital, Elvira Universidad de Zaragoza (orcid)0000-0003-2710-1875 Fernández-Espinosa, Guisela Universidad de Zaragoza (orcid)0000-0003-1234-9712 Bielsa Alonso, Sofia Acha-Pérez, Javier (orcid)0000-0002-2987-6351 Rodriguez-Mena, Diego Universidad de Zaragoza Pinilla, Isabel Universidad de Zaragoza (orcid)0000-0003-0349-9997 1007 610 Universidad de Zaragoza Dpto. Medicina, Psiqu. y Derm. Area Medicina 1013 646 Universidad de Zaragoza Dpto. Cirugía Área Oftalmología 2002 647 Universidad de Zaragoza Dpto. Física Aplicada Área Óptica 14, 3520 (2024), 1-13 Sci. rep. (Nat. Publ. Group) Scientific reports (Nature Publishing Group) 2045-2322 1262212 http://zaguan.unizar.es/record/131798/files/texto_completo.pdf Versión publicada 2426219 http://zaguan.unizar.es/record/131798/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:131798 articulos driver 2026-02-17-20:23:05 ARTICLE