131799 20241125101200.0 doi 10.3389/fimmu.2023.1277793 sideral 137164 ART-2023-137164 deu Ayerdi, Oskar HTLV infection in persons with sexually transmitted diseases in Spain 2023 Access copy available to the general public Unrestricted Background: HTLV-1 infection is a neglected disease, despite estimates of 10 million people infected worldwide and producing life-threatening illnesses in 10% of carriers. Sexual transmission is the main route of contagion. However, HTLV-1 is not listed among sexually transmitted infections (STIs). Methods: Serum from all consecutive individuals who had attended six STI clinics across Spain during the last 12 months were tested for HTLV antibodies using a commercial enzyme immunoassay (EIA). Reactive samples were confirmed by immunoblot. Results: A total of 2,524 samples were examined. The majority (1,936; 76.7%) belonged to men, of whom 676 (34.9%) were men who have sex with men (MSM) receiving HIV pre-exposure prophylaxis. Although native Spaniards predominated (1,470; 58.2%), up to 593 (23.5%) came from Latin America and 139 (5.5%) were African. A total of 26 individuals were initially EIA reactive and immunoblot confirmed 5 as HTLV-1 and 7 as HTLV-2. All but one HTLV-1+ case came from Latin America. Three were men and two were women. Among Latin Americans, the HTLV-1 seroprevalence was 0.67%. In contrast, all seven HTLV-2+ were native Spaniards and former injection drug users, and all but one were HIV+. Conclusion: The rate of HTLV infection among individuals with STIs in Spain is 0.5%, which is greater than in the general population. These results support the introduction of universal HTLV screening in persons who attend clinics for STIs. info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI21-1717 info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 5.7 2023 IMMUNOLOGY 37 / 181 = 0.204 2023 Q1 T1 1.868 2023 Immunology and Allergy 2023 Q1 Immunology 2023 Q1 9.8 2023 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Benito, Rafael Universidad de Zaragoza (orcid)0000-0001-5134-1006 Ortega, Diego Universidad de Zaragoza Aguilera, Antonio Montiel, Natalia Pintos, Ilduara Díaz de Santiago, Alberto Baza, Begoña Soriano, Vicente de Mendoza, Carmen 1011 630 Universidad de Zaragoza Dpto. Microb.Ped.Radio.Sal.Pú. Área Microbiología 14 (2023), 1277793 [6 pp.] Front. immunol. Frontiers in Immunology 1664-3224 317748 http://zaguan.unizar.es/record/131799/files/texto_completo.pdf Versión publicada 1863428 http://zaguan.unizar.es/record/131799/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:131799 articulos driver 2024-11-22-12:11:04 ARTICLE