000131811 001__ 131811
000131811 005__ 20241125101140.0
000131811 0247_ $$2doi$$a10.2147/PPA.S411069
000131811 0248_ $$2sideral$$a137003
000131811 037__ $$aART-2023-137003
000131811 041__ $$aeng
000131811 100__ $$aSainz de la Maza, Susana
000131811 245__ $$aHopelessness in Patients with Early-Stage Relapsing-Remitting Multiple Sclerosis
000131811 260__ $$c2023
000131811 5060_ $$aAccess copy available to the general public$$fUnrestricted
000131811 5203_ $$aBackground: Hopelessness is a risk factor for depression and suicide. There is little information on this phenomenon among patients with relapsing-remitting multiple sclerosis (RRMS), one of the most common causes of disability and loss of autonomy in young adults. The aim of this study was to assess state hopelessness and its associated factors in early-stage RRMS.
Methods: A multicenter, non-interventional study was conducted. Adult patients with a diagnosis of RRMS, a disease duration ≤ 3 years, and an Expanded Disability Status Scale (EDSS) score of 0– 5.5 were included. The State-Trait Hopelessness Scale (STHS) was used to measure patients´ hopelessness. A battery of patient-reported and clinician-rated measurements was used to assess clinical status. A multivariate logistic regression analysis was conducted to determine the association between patients’ characteristics and state hopelessness.
Results: A total of 189 patients were included. Mean age (standard deviation-SD) was 36.1 (9.4) years and 71.4% were female. Median disease duration (interquartile range-IQR) was 1.4 (0.7, 2.1) years. Symptom severity and disability were low with a median EDSS (IQR) score of 1.0 (0, 2.0). A proportion of 65.6% (n=124) of patients reported moderate-to-severe hopelessness. Hopelessness was associated with older age (p=0.035), depressive symptoms (p=< 0.001), a threatening illness perception (p=0.001), and psychological and cognitive barriers to workplace performance (p=0.029) in the multivariate analysis after adjustment for confounders.
Conclusion: Hopelessness was a common phenomenon in early-stage RRMS, even in a population with low physical disability. Identifying factors associated with hopelessness may be critical for implementing preventive strategies helping patients to adapt to the new situation and cope with the disease in the long term.
000131811 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc$$uhttp://creativecommons.org/licenses/by-nc/3.0/es/
000131811 590__ $$a2.0$$b2023
000131811 592__ $$a0.647$$b2023
000131811 591__ $$aMEDICINE, GENERAL & INTERNAL$$b102 / 329 = 0.31$$c2023$$dQ2$$eT1
000131811 593__ $$aPharmacology, Toxicology and Pharmaceutics (miscellaneous)$$c2023$$dQ1
000131811 593__ $$aSocial Sciences (miscellaneous)$$c2023$$dQ1
000131811 593__ $$aHealth Policy$$c2023$$dQ2
000131811 593__ $$aMedicine (miscellaneous)$$c2023$$dQ2
000131811 594__ $$a3.6$$b2023
000131811 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000131811 700__ $$aMaurino, Jorge
000131811 700__ $$aCastillo-Triviño, Tamara
000131811 700__ $$aBorges, Mónica
000131811 700__ $$aSebastián Torres, Berta
000131811 700__ $$aSotoca, Javier
000131811 700__ $$aAlonso Torres, Ana María
000131811 700__ $$aCaminero, Ana B.
000131811 700__ $$aBorrega, Laura
000131811 700__ $$aSánchez-Menoyo, José L.
000131811 700__ $$aBarrero-Hernández, Francisco J.
000131811 700__ $$aCalles, Carmen
000131811 700__ $$aBrieva, Luis
000131811 700__ $$aBlasco, María Rosario
000131811 700__ $$aDotor García-Soto, Julio
000131811 700__ $$aRodríguez-Regal, Ana
000131811 700__ $$aNavarro-Cantó, Laura
000131811 700__ $$aAgüera-Morales, Eduardo
000131811 700__ $$0(orcid)0000-0002-1756-5492$$aGarcés, Moisés$$uUniversidad de Zaragoza
000131811 700__ $$aCarmona, Olga
000131811 700__ $$aGabaldón-Torres, Laura
000131811 700__ $$aForero, Lucía
000131811 700__ $$aHervás, Mariona
000131811 700__ $$aGómez-Ballesteros, Rocío
000131811 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000131811 773__ $$g17 (2023), 1431-1439$$pPATIENT PREFERENCE AND ADHERENCE$$tPATIENT PREFERENCE AND ADHERENCE$$x1177-889X
000131811 8564_ $$s555803$$uhttps://zaguan.unizar.es/record/131811/files/texto_completo.pdf$$yVersión publicada
000131811 8564_ $$s2873940$$uhttps://zaguan.unizar.es/record/131811/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000131811 909CO $$ooai:zaguan.unizar.es:131811$$particulos$$pdriver
000131811 951__ $$a2024-11-22-12:02:30
000131811 980__ $$aARTICLE