000131825 001__ 131825
000131825 005__ 20240319081030.0
000131825 0247_ $$2doi$$a10.1016/j.msard.2021.103398
000131825 0248_ $$2sideral$$a137006
000131825 037__ $$aART-2022-137006
000131825 041__ $$aeng
000131825 100__ $$aSainz de la Maza, Susana
000131825 245__ $$aMeasuring productivity loss in early relapsing-remitting multiple sclerosis
000131825 260__ $$c2022
000131825 5203_ $$aBackground
Multiple sclerosis is one of the most common causes of neurological disability in young adults with major consequences for their autonomy and capacity to maintain employment.
Objective
The aim of this study was to assess the impact on work productivity in early-stage relapsing-remitting multiple sclerosis (RRMS).
Methods
A multicenter, non-interventional study was conducted. Adult patients with a diagnosis of RRMS, a disease duration ≤ 3 years, and an Expanded Disability Status Scale (EDSS) score of 0–5.5 were included. Absenteeism, presenteeism, and unpaid work loss due to RRMS were measured using the Valuation of Lost Productivity (VOLP) questionnaire. The EDSS, SymptoMScreen, 5-item Modified Fatigue Impact Scale, Hospital Anxiety and Depression Scale, Symbol Digit Modalities Test, and Multiple Sclerosis Work Difficulties Questionnaire were used to gather information on disability, patients’ perception of symptom severity, fatigue, mood/anxiety, cognition, and problems in the workplace, respectively. Associations between the VOLP and clinical and work outcomes were analyzed using Spearman's rank correlations.
Results
A total of 189 patients were included. Mean age (SD) was 36.1 ± 9.4 years and 71.4% were female. Mean disease duration was 1.2 ± 0.8 years. Median EDSS score was 1.0 (IQR 0, 2.0). One hundred thirty patients (68.8%) were working for pay or self-employed. Fifty-three patients (40.8%) reported absence from work in the past 3 months with an average of 14.3 absent workdays. Their health problems resulted in the loss of 3.4% of their actual work time in the past 7 days. Thirty patients got help (11.8 h) with their unpaid work activities in the past 7 days. Absenteeism was significantly correlated with anxiety and depression (rho=0.298 and 0.291, p<0.001), fatigue (rho=0.214, p = 0.014), and symptom severity (rho=0.213, p = 0.015). Presenteeism was significantly correlated with fatigue (rho=0.375, p<0.001), symptom severity (rho=0.373, p<0.001), depression (rho=0.263, p = 0.008), and disability (rho=0.215, p = 0.031).
Conclusions
Productivity loss even in a RRMS population with short disease duration stresses the need for more efficient treatment control of disease activity from earlier stages.
000131825 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000131825 590__ $$a4.0$$b2022
000131825 591__ $$aCLINICAL NEUROLOGY$$b69 / 212 = 0.325$$c2022$$dQ2$$eT1
000131825 592__ $$a0.92$$b2022
000131825 593__ $$aMedicine (miscellaneous)$$c2022$$dQ1
000131825 593__ $$aNeurology (clinical)$$c2022$$dQ2
000131825 593__ $$aNeurology$$c2022$$dQ2
000131825 594__ $$a5.6$$b2022
000131825 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000131825 700__ $$aMaurino, Jorge
000131825 700__ $$aBorges, Mónica
000131825 700__ $$aMartín-Martínez, Jesús
000131825 700__ $$aSotoca, Javier
000131825 700__ $$aAlonso, Ana
000131825 700__ $$aCaminero, Ana B.
000131825 700__ $$aBorrega, Laura
000131825 700__ $$aSánchez-Menoyo, José L.
000131825 700__ $$aBarrero-Hernández, Francisco J.
000131825 700__ $$aCalles, Carmen
000131825 700__ $$aBrieva, Luis
000131825 700__ $$aBlasco, Maria R.
000131825 700__ $$aDotor García-Soto, Julio
000131825 700__ $$aCampo-Amigo, María del
000131825 700__ $$aNavarro-Cantó, Laura
000131825 700__ $$aAgüera, Eduardo
000131825 700__ $$0(orcid)0000-0002-1756-5492$$aGarcés, Moisés$$uUniversidad de Zaragoza
000131825 700__ $$aCarmona, Olga
000131825 700__ $$aGabaldón-Torres, Laura
000131825 700__ $$aForero, Lucía
000131825 700__ $$aHervás, Mariona
000131825 700__ $$aRuiz de Alda, Lucía
000131825 700__ $$aGómez-Ballesteros, Rocío
000131825 700__ $$aCastillo-Triviño, Tamara
000131825 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000131825 773__ $$g58 (2022), 103398 [5 pp.]$$pMult. scler. relat. disord.$$tMultiple Sclerosis and Related Disorders$$x2211-0348
000131825 8564_ $$s443207$$uhttps://zaguan.unizar.es/record/131825/files/texto_completo.pdf$$yVersión publicada
000131825 8564_ $$s2265979$$uhttps://zaguan.unizar.es/record/131825/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000131825 909CO $$ooai:zaguan.unizar.es:131825$$particulos$$pdriver
000131825 951__ $$a2024-03-18-17:06:57
000131825 980__ $$aARTICLE