000131851 001__ 131851
000131851 005__ 20250908131406.0
000131851 0247_ $$2doi$$a10.1002/vrc2.779
000131851 0248_ $$2sideral$$a137194
000131851 037__ $$aART-2023-137194
000131851 041__ $$aeng
000131851 100__ $$0(orcid)0000-0001-6209-4282$$aVillanueva-Saz, Sergio$$uUniversidad de Zaragoza
000131851 245__ $$aProliferative papulo-nodular glossitis due to <i>Leishmania infantum</i> in a dog
000131851 260__ $$c2023
000131851 5060_ $$aAccess copy available to the general public$$fUnrestricted
000131851 5203_ $$aCanine leishmaniosis, caused by the protozoan Leishmania infantum, is an endemic vector‐borne disease in Europe. From a diagnostic point of view, the disease can sometimes be a real challenge for the clinician, due to the variability of clinical presentations in a sick dog. These clinical signs can be classified, based on the frequency of presentation, in typical and atypical signs. In dogs is common to find different clinical presentations of cutaneous disease and systemic involvement, while clinical presentations in mucosa are not so common. A 6‐year‐old, entire, male German shepherd crossbred dog was examined for evident nodular lesions on the tongue. The most important laboratory alteration detected was hyperglobulinemia with an increase in the gamma fraction classified as polyclonal gammopathy. High anti‐Leishmania antibodies were detected by ELISA. Tongue biopsy samples were obtained from the lesions with the presence of a diffuse inflammatory infiltrate characterised by macrophages and neutrophils with no compatible forms of Leishmania parasites. However, the presence of Leishmania amastigotes was confirmed by specific immunohistochemistry. A good clinical response to the anti‐Leishmania based on meglumine antimoniate and allopurinol was observed after meglumine antimoniate administration. This clinical case describes the presentation of proliferative papulo‐nodular glossitis in an L. infantum‐positive dog as the most evident clinical finding reported.
000131851 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000131851 592__ $$a0.183$$b2023
000131851 593__ $$aVeterinary (miscellaneous)$$c2023$$dQ3
000131851 594__ $$a0.5$$b2023
000131851 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000131851 700__ $$aPérez, Estela$$uUniversidad de Zaragoza
000131851 700__ $$aYzuel, Andrés
000131851 700__ $$0(orcid)0000-0002-9723-9004$$aGómez, Alex$$uUniversidad de Zaragoza
000131851 700__ $$0(orcid)0000-0003-2957-1379$$aVerde Arribas, María Teresa$$uUniversidad de Zaragoza
000131851 7102_ $$11009$$2773$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Sanidad Animal
000131851 7102_ $$11009$$2617$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Medicina y Cirugía Animal
000131851 773__ $$g12, 1 (2023), e779 [6 pp.]$$pVet. rec. case rep.$$tVeterinary Record Case Reports$$x2052-6121
000131851 8564_ $$s1561736$$uhttps://zaguan.unizar.es/record/131851/files/texto_completo.pdf$$yVersión publicada
000131851 8564_ $$s2825793$$uhttps://zaguan.unizar.es/record/131851/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000131851 909CO $$ooai:zaguan.unizar.es:131851$$particulos$$pdriver
000131851 951__ $$a2025-09-08-12:49:37
000131851 980__ $$aARTICLE