000131863 001__ 131863
000131863 005__ 20240731103412.0
000131863 0247_ $$2doi$$a10.4103/jmh.jmh_115_23
000131863 0248_ $$2sideral$$a137117
000131863 037__ $$aART-2023-137117
000131863 041__ $$aeng
000131863 100__ $$aGarcía-Alfaro, Pascual
000131863 245__ $$aAssociation of Endogenous Hormones and Bone Mineral Density in Postmenopausal Women
000131863 260__ $$c2023
000131863 5060_ $$aAccess copy available to the general public$$fUnrestricted
000131863 5203_ $$aAim: The aim of this study was to examine the association between endogenous hormones and bone mineral density (BMD) in postmenopausal women. Materials and Methods: This was a cross-sectional study of 798 postmenopausal women aged 47-85 years. Data were collected on age, age at menopause, years since menopause, smoking status, body mass index, adiposity, BMD, physical activity, and Vitamin D supplementation. Measured hormonal parameters were: follicle-stimulating hormone (FSH), estradiol, testosterone, dehydroepiandrosterone sulfate, 4-androstenedione, cortisol, insulin-like growth factor-1, 25-hydroxyvitamin D, and parathormone (PTH) levels. BMD was measured at the lumbar spine, femoral neck, and total hip using dual-energy X-ray absorptiometry. A directed acyclic graph was used to select potential confounding variables. Results: Multivariable analysis showed significant associations between cortisol and femoral neck BMD (β: -0.02, 95% confidence interval [CI]: -0.03 - 0.00), and PTH with femoral neck BMD (β: -0.01, 95% CI: -0.02 - 0.01) and total hip BMD (β: -0.01, 95% CI: -0.01 - 0.00). Hormonal factors more likely associated with a higher risk of low BMD (osteopenia or osteoporosis) were FSH (odds ratio [OR]: 1.02, 95% CI: 1.01-1.03) and PTH (OR: 1.02, 95% CI: 1.01-1.04). Conclusions: Higher cortisol and PTH levels were inversely associated with BMD. Postmenopausal women with higher FSH or PTH levels were likely to have low BMD. © 2023 Journal of Mid-life Health.
000131863 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-sa$$uhttp://creativecommons.org/licenses/by-nc-sa/3.0/es/
000131863 592__ $$a0.371$$b2023
000131863 593__ $$aMedicine (miscellaneous)$$c2023$$dQ3
000131863 593__ $$aHealth (social science)$$c2023$$dQ3
000131863 594__ $$a1.7$$b2023
000131863 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000131863 700__ $$aGarcía, Sandra
000131863 700__ $$aRodriguez, Ignacio
000131863 700__ $$aPascual, Maria Angela
000131863 700__ $$0(orcid)0000-0002-2801-416X$$aPérez-López, Faustino R.
000131863 773__ $$g14, 3 (2023), 196-204$$tJournal of Mid-Life Health$$x0976-7800
000131863 8564_ $$s764338$$uhttps://zaguan.unizar.es/record/131863/files/texto_completo.pdf$$yVersión publicada
000131863 8564_ $$s3111901$$uhttps://zaguan.unizar.es/record/131863/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000131863 909CO $$ooai:zaguan.unizar.es:131863$$particulos$$pdriver
000131863 951__ $$a2024-07-31-10:04:37
000131863 980__ $$aARTICLE