doi:10.1177/20552173231169475engSainz de la Maza, SusanaGómez-Ballesteros, RocíoBorges, MónicaMartín-Martínez, JesúsSotoca, JavierAlonso, AnaCaminero, Ana B.Borrega, LauraSánchez-Menoyo, José L.Barrero-Hernández, Francisco J.Calles, CarmenBrieva, LuisBlasco-Quílez, María R.Dotor García-Soto, JulioCampo-Amigo, María delNavarro-Cantó, LauraAgüera, EduardoGarcés-Redondo, MoisésCarmona, OlgaGabaldón-Torres, LauraForero, LucíaHervàs, MarionaMedrano, NicolásMaurino, JorgeCastillo-Triviño, TamaraDetecting disability using self-reported and clinical assessments in early-stage relapsing-remitting multiple sclerosis: Looking for a complementary approachART-2023-137002Disability accrual is mainly driven by progression independent of relapse activity, which is present even in early stages of relapsing-remitting multiple sclerosis (RRMS) and sometimes overlooked. This multicenter, non-interventional study evaluated whether patient-reported outcomes measures (PROMs) could capture disability in 189 early-stage RRMS patients (mean age: 36.1 ± 9.4 years, 71.4% female, mean disease duration: 1.4 ± 0.8 years, median EDSS: 1.0). The 9-Hole Peg Test (9-HPT), NeuroQoL Upper Extremity (NeuroQoL-UE), Timed 25-Foot Walk (T25-FW), Multiple Sclerosis Walking Scale (MSWS-12), Symbol Digit Modalities Test (SDMT), and Perceived Deficits Questionnaire (PDQ-5) were used to assess hand function, gait, and cognition, respectively. These functions were at least mildly affected in this early-stage population, finding significant correlations between PROMs and clinical assessments. PROMs could enable early-stage RRMS patients to communicate their perceived disability in different domains, assisting clinicians in disease monitoring and decision making.2023http://zaguan.unizar.es/record/13189410.1177/20552173231169475http://zaguan.unizar.es/record/131894oai:zaguan.unizar.es:131894Multiple Sclerosis Journal - Experimental, Translational and Clinical 9, 2 (2023), [7 pp.]by-nchttp://creativecommons.org/licenses/by-nc/3.0/es/info:eu-repo/semantics/openAccess