000132078 001__ 132078
000132078 005__ 20240301161205.0
000132078 0247_ $$2doi$$a10.1021/acs.oprd.9b00411
000132078 0248_ $$2sideral$$a116919
000132078 037__ $$aART-2020-116919
000132078 041__ $$aeng
000132078 100__ $$0(orcid)0000-0002-3256-2089$$aLeal-Duaso, Alejandro$$uUniversidad de Zaragoza
000132078 245__ $$aReadily scalable methodology for the synthesis of nonsymmetric glyceryl diethers by a tandem acid-/base-catalyzed process
000132078 260__ $$c2020
000132078 5060_ $$aAccess copy available to the general public$$fUnrestricted
000132078 5203_ $$aA useful optimized synthetic methodology has been designed for the synthesis of nonsymmetric glyceryl diethers from epichlorohydrin. A tandem process combining a cheap, heterogeneous, and fully recoverable acid catalyst and alkaline hydroxide is used for the synthesis of a variety of glycerol-derived ethers bearing different alkyl substituents in 1 and 3 positions. Different heterogeneous acid catalysts have been tested for the reaction of epichlorohydrin with several alcohols, the best results being obtained with readily available recoverable and inexpensive montmorillonite-K10 and Nafion NR50. For the second reaction step, potassium hydroxide is used. In all the cases, good yields of the desired glyceryl diethers are obtained in smooth reaction conditions, always with total conversion of epichlorohydrin and without the need of intermediate purification. Scale-up of the tandem process has been carried out with good results.
000132078 536__ $$9info:eu-repo/grantAgreement/ES/DGA/E37-17R$$9info:eu-repo/grantAgreement/ES/MCIU/RTI2018-093431-B-I00
000132078 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000132078 590__ $$a3.317$$b2020
000132078 591__ $$aCHEMISTRY, ORGANIC$$b20 / 57 = 0.351$$c2020$$dQ2$$eT2
000132078 591__ $$aCHEMISTRY, APPLIED$$b26 / 74 = 0.351$$c2020$$dQ2$$eT2
000132078 592__ $$a0.904$$b2020
000132078 593__ $$aPhysical and Theoretical Chemistry$$c2020$$dQ1
000132078 593__ $$aOrganic Chemistry$$c2020$$dQ1
000132078 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000132078 700__ $$aGracia-Barberán, Sara
000132078 700__ $$0(orcid)0000-0003-1570-4257$$aMayoral, José A.$$uUniversidad de Zaragoza
000132078 700__ $$0(orcid)0000-0003-1199-2087$$aGarcía, José I.
000132078 700__ $$0(orcid)0000-0002-2676-8814$$aPires, Elisabet$$uUniversidad de Zaragoza
000132078 7102_ $$12013$$2765$$aUniversidad de Zaragoza$$bDpto. Química Orgánica$$cÁrea Química Orgánica
000132078 773__ $$g24, 2 (2020), 154-162$$pOrg. process res. dev.$$tORGANIC PROCESS RESEARCH & DEVELOPMENT$$x1083-6160
000132078 8564_ $$s871034$$uhttps://zaguan.unizar.es/record/132078/files/texto_completo.pdf$$yPostprint
000132078 8564_ $$s1089856$$uhttps://zaguan.unizar.es/record/132078/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000132078 909CO $$ooai:zaguan.unizar.es:132078$$particulos$$pdriver
000132078 951__ $$a2024-03-01-14:37:57
000132078 980__ $$aARTICLE