000132125 001__ 132125
000132125 005__ 20240711085510.0
000132125 0247_ $$2doi$$a10.1093/jmammal/gyae008
000132125 0248_ $$2sideral$$a137294
000132125 037__ $$aART-2024-137294
000132125 041__ $$aeng
000132125 100__ $$aStipoljev, Suncica
000132125 245__ $$aDiversity of MHC class II DRB alleles in the Northern chamois genus Rupicapra
000132125 260__ $$c2024
000132125 5203_ $$aMajor histocompatibility complex (MHC) genes are commonly used markers for monitoring adaptive genetic and evolutionary potential of species. In this study, we investigated genetic variation of the MHC class II DRB locus in the chamois genus Rupicapra by using next-generation sequencing. Sequencing of 102 samples led to the identification of 25 alleles, 11 of which are novel. The high ratio of the relative rates of nonsynonymous to synonymous mutations (dN/dS) suggests a signal of positive selection on this locus. We analyzed patterns of genetic variation within and among 2 subspecies of Northern Chamois and compared them to previously published studies using neutral markers to provide a basis for assessing the effects of demographic processes. Our analyses have shown that alleles are likely to be maintained by balancing selection in different populations with similar frequencies and that this mechanism also works in small, isolated populations that are strongly affected by genetic drift.
000132125 536__ $$9info:eu-repo/grantAgreement/EC/H2020/872146/EU/RESponsible research and innovation grounding practices in BIOSciencies/RESBIOS$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 872146-RESBIOS
000132125 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000132125 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000132125 700__ $$aBuzan, Elena
000132125 700__ $$aIacolina, Laura
000132125 700__ $$aSafner, Toni
000132125 700__ $$aRezic, Andrea
000132125 700__ $$aGalov, Ana
000132125 700__ $$aKrižanovic, Krešimir
000132125 700__ $$aAmbarli, Hüseyin
000132125 700__ $$0(orcid)0000-0002-6770-3400$$aArnal, MariaCruz$$uUniversidad de Zaragoza
000132125 700__ $$aBabaev, Elmar
000132125 700__ $$aBego, Ferdinand
000132125 700__ $$aFarkas, Attila
000132125 700__ $$aGacic, Dragan
000132125 700__ $$aLazar, Peter
000132125 700__ $$aMaletic, Vladimir
000132125 700__ $$aMarkov, Georgi
000132125 700__ $$aMiloševic, Dragana
000132125 700__ $$aPapaioannou, Haritakis
000132125 700__ $$aScandura, Massimo
000132125 700__ $$aŠprem, Nikica
000132125 7102_ $$11009$$2773$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Sanidad Animal
000132125 773__ $$g105, 2 (2024), 312–322$$pJ. mammal.$$tJOURNAL OF MAMMALOGY$$x0022-2372
000132125 8564_ $$s7045474$$uhttps://zaguan.unizar.es/record/132125/files/texto_completo.pdf$$yVersión publicada
000132125 8564_ $$s2775883$$uhttps://zaguan.unizar.es/record/132125/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000132125 909CO $$ooai:zaguan.unizar.es:132125$$particulos$$pdriver
000132125 951__ $$a2024-07-11-08:52:27
000132125 980__ $$aARTICLE