132125 20260217205453.0 doi 10.1093/jmammal/gyae008 sideral 137294 ART-2024-137294 eng Stipoljev, Suncica Diversity of MHC class II DRB alleles in the Northern chamois genus Rupicapra 2024 Major histocompatibility complex (MHC) genes are commonly used markers for monitoring adaptive genetic and evolutionary potential of species. In this study, we investigated genetic variation of the MHC class II DRB locus in the chamois genus Rupicapra by using next-generation sequencing. Sequencing of 102 samples led to the identification of 25 alleles, 11 of which are novel. The high ratio of the relative rates of nonsynonymous to synonymous mutations (dN/dS) suggests a signal of positive selection on this locus. We analyzed patterns of genetic variation within and among 2 subspecies of Northern Chamois and compared them to previously published studies using neutral markers to provide a basis for assessing the effects of demographic processes. Our analyses have shown that alleles are likely to be maintained by balancing selection in different populations with similar frequencies and that this mechanism also works in small, isolated populations that are strongly affected by genetic drift. info:eu-repo/grantAgreement/EC/H2020/872146/EU/RESponsible research and innovation grounding practices in BIOSciencies/RESBIOS This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 872146-RESBIOS info:eu-repo/semantics/closedAccess All rights reserved http://www.europeana.eu/rights/rr-f/ 1.6 2024 ZOOLOGY 53 / 182 = 0.291 2024 Q2 T1 0.641 2024 Animal Science and Zoology 2024 Q1 Nature and Landscape Conservation 2024 Q2 Ecology 2024 Q2 Ecology, Evolution, Behavior and Systematics 2024 Q2 Genetics 2024 Q3 3.3 2024 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Buzan, Elena Iacolina, Laura Safner, Toni Rezic, Andrea Galov, Ana Križanovic, Krešimir Ambarli, Hüseyin Arnal, MariaCruz Universidad de Zaragoza (orcid)0000-0002-6770-3400 Babaev, Elmar Bego, Ferdinand Farkas, Attila Gacic, Dragan Lazar, Peter Maletic, Vladimir Markov, Georgi Miloševic, Dragana Papaioannou, Haritakis Scandura, Massimo Šprem, Nikica 1009 773 Universidad de Zaragoza Dpto. Patología Animal Área Sanidad Animal 105, 2 (2024), 312–322 J. mammal. JOURNAL OF MAMMALOGY 0022-2372 7045474 http://zaguan.unizar.es/record/132125/files/texto_completo.pdf Versión publicada 2775883 http://zaguan.unizar.es/record/132125/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:132125 articulos driver 2026-02-17-20:19:30 ARTICLE