000132126 001__ 132126 000132126 005__ 20240301161206.0 000132126 0247_ $$2doi$$a10.3390/ijms25042152 000132126 0248_ $$2sideral$$a137276 000132126 037__ $$aART-2024-137276 000132126 041__ $$aeng 000132126 100__ $$0(orcid)0000-0002-1657-4792$$aGuerrero-Ochoa, Patricia 000132126 245__ $$aProstate cancer and the Mevalonate pathway 000132126 260__ $$c2024 000132126 5060_ $$aAccess copy available to the general public$$fUnrestricted 000132126 5203_ $$aAntineoplastic therapies for prostate cancer (PCa) have traditionally centered around the androgen receptor (AR) pathway, which has demonstrated a significant role in oncogenesis. Nevertheless, it is becoming progressively apparent that therapeutic strategies must diversify their focus due to the emergence of resistance mechanisms that the tumor employs when subjected to monomolecular treatments. This review illustrates how the dysregulation of the lipid metabolic pathway constitutes a survival strategy adopted by tumors to evade eradication efforts. Integrating this aspect into oncological management could prove valuable in combating PCa. 000132126 536__ $$9info:eu-repo/grantAgreement/ES/DGA/T69-23R 000132126 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/ 000132126 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000132126 700__ $$0(orcid)0000-0003-3880-3821$$aRodríguez-Zapater, Sergio$$uUniversidad de Zaragoza 000132126 700__ $$0(orcid)0000-0002-5175-8394$$aAnel, Alberto$$uUniversidad de Zaragoza 000132126 700__ $$0(orcid)0000-0002-3007-302X$$aEsteban, Luis Mariano 000132126 700__ $$aCamón-Fernández, Alejandro 000132126 700__ $$aEspilez-Ortiz, Raquel 000132126 700__ $$0(orcid)0000-0002-0586-8138$$aGil-Sanz, María Jesús$$uUniversidad de Zaragoza 000132126 700__ $$0(orcid)0000-0003-0178-4567$$aBorque-Fernando, Ángel$$uUniversidad de Zaragoza 000132126 7102_ $$11002$$2060$$aUniversidad de Zaragoza$$bDpto. Bioq.Biolog.Mol. Celular$$cÁrea Bioquímica y Biolog.Mole. 000132126 7102_ $$11009$$2617$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Medicina y Cirugía Animal 000132126 7102_ $$11013$$2817$$aUniversidad de Zaragoza$$bDpto. Cirugía$$cÁrea Urología 000132126 773__ $$g25, 4 (2024), 2152 [21 pp.]$$pInt. j. mol. sci.$$tInternational Journal of Molecular Sciences$$x1661-6596 000132126 8564_ $$s3909216$$uhttps://zaguan.unizar.es/record/132126/files/texto_completo.pdf$$yVersión publicada 000132126 8564_ $$s2709006$$uhttps://zaguan.unizar.es/record/132126/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000132126 909CO $$ooai:zaguan.unizar.es:132126$$particulos$$pdriver 000132126 951__ $$a2024-03-01-14:50:07 000132126 980__ $$aARTICLE