132126 20260217205453.0 doi 10.3390/ijms25042152 sideral 137276 ART-2024-137276 eng Guerrero-Ochoa, Patricia (orcid)0000-0002-1657-4792 Prostate cancer and the Mevalonate pathway 2024 Access copy available to the general public Unrestricted Antineoplastic therapies for prostate cancer (PCa) have traditionally centered around the androgen receptor (AR) pathway, which has demonstrated a significant role in oncogenesis. Nevertheless, it is becoming progressively apparent that therapeutic strategies must diversify their focus due to the emergence of resistance mechanisms that the tumor employs when subjected to monomolecular treatments. This review illustrates how the dysregulation of the lipid metabolic pathway constitutes a survival strategy adopted by tumors to evade eradication efforts. Integrating this aspect into oncological management could prove valuable in combating PCa. info:eu-repo/grantAgreement/ES/DGA/T69-23R info:eu-repo/semantics/openAccess by https://creativecommons.org/licenses/by/4.0/deed.es 4.9 2024 BIOCHEMISTRY & MOLECULAR BIOLOGY 72 / 320 = 0.225 2024 Q1 T1 CHEMISTRY, MULTIDISCIPLINARY 70 / 239 = 0.293 2024 Q2 T1 1.273 2024 Medicine (miscellaneous) 2024 Q1 Physical and Theoretical Chemistry 2024 Q1 Computer Science Applications 2024 Q1 Inorganic Chemistry 2024 Q1 Spectroscopy 2024 Q1 Organic Chemistry 2024 Q1 Molecular Biology 2024 Q2 Catalysis 2024 Q2 9.0 2024 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Rodríguez-Zapater, Sergio Universidad de Zaragoza (orcid)0000-0003-3880-3821 Anel, Alberto Universidad de Zaragoza (orcid)0000-0002-5175-8394 Esteban, Luis Mariano (orcid)0000-0002-3007-302X Camón-Fernández, Alejandro Espilez-Ortiz, Raquel Gil-Sanz, María Jesús Universidad de Zaragoza (orcid)0000-0002-0586-8138 Borque-Fernando, Ángel Universidad de Zaragoza (orcid)0000-0003-0178-4567 1002 060 Universidad de Zaragoza Dpto. Bioq.Biolog.Mol. Celular Área Bioquímica y Biolog.Mole. 1009 617 Universidad de Zaragoza Dpto. Patología Animal Área Medicina y Cirugía Animal 1013 817 Universidad de Zaragoza Dpto. Cirugía Área Urología 25, 4 (2024), 2152 [21 pp.] Int. j. mol. sci. International Journal of Molecular Sciences 1661-6596 3909216 http://zaguan.unizar.es/record/132126/files/texto_completo.pdf Versión publicada 2709006 http://zaguan.unizar.es/record/132126/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:132126 articulos driver 2026-02-17-20:19:31 ARTICLE