132136 20260218073109.0 doi 10.1002/smll.202309283 sideral 137297 ART-2024-137297 eng Kirbas Cilingir, Emel Small Warriors of Nature: Novel Red Emissive Chlorophyllin Carbon Dots Harnessing Fenton-Fueled Ferroptosis for In Vitro and In Vivo Cancer Treatment 2024 Access copy available to the general public Unrestricted The appeal of carbon dots (CDs) has grown recently, due to their established biocompatibility, adjustable photoluminescence properties, and excellent water solubility. For the first time in the literature, copper chlorophyllin‐based carbon dots (Chl‐D CDs) are successfully synthesized. Chl‐D CDs exhibit unique spectroscopic traits and are found to induce a Fenton‐like reaction, augmenting photodynamic therapy (PDT) efficacies via ferroptotic and apoptotic pathways. To bolster the therapeutic impact of Chl‐D CDs, a widely used cancer drug, temozolomide, is linked to their surface, yielding a synergistic effect with PDT and chemotherapy. Chl‐D CDs' biocompatibility in immune cells and in vivo models showed great clinical potential.Proteomic analysis was conducted to understand Chl‐D CDs' underlying cancer treatment mechanism. The study underscores the role of reactive oxygen species formation and pointed toward various oxidative stress modulators like aldolase A (ALDOA), aldolase C (ALDOC), aldehyde dehydrogenase 1B1 (ALDH1B1), transaldolase 1 (TALDO1), and transketolase (TKT), offering a deeper understanding of the Chl‐D CDs' anticancer activity. Notably, the Chl‐D CDs' capacity to trigger a Fenton‐like reaction leads to enhanced PDT efficiencies through ferroptotic and apoptotic pathways. Hence, it is firmly believed that the inherent attributes of Chl‐CDs can lead to a secure and efficient combined cancer therapy. info:eu-repo/grantAgreement/EC/H2020/742684/EU/Catalytic Dual-Function Devices Against Cancer/CADENCE This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 742684-CADENCE info:eu-repo/grantAgreement/ES/MICINN/CNS2022-135911 info:eu-repo/semantics/openAccess All rights reserved http://www.europeana.eu/rights/rr-f/ 12.1 2024 CHEMISTRY, PHYSICAL 24 / 185 = 0.13 2024 Q1 T1 MATERIALS SCIENCE, MULTIDISCIPLINARY 42 / 461 = 0.091 2024 Q1 T1 NANOSCIENCE & NANOTECHNOLOGY 17 / 147 = 0.116 2024 Q1 T1 PHYSICS, CONDENSED MATTER 8 / 80 = 0.1 2024 Q1 T1 CHEMISTRY, MULTIDISCIPLINARY 24 / 239 = 0.1 2024 Q1 T1 PHYSICS, APPLIED 14 / 187 = 0.075 2024 Q1 T1 3.301 2024 Biomaterials 2024 Q1 Biotechnology 2024 Q1 Chemistry (miscellaneous) 2024 Q1 Nanoscience and Nanotechnology 2024 Q1 Materials Science (miscellaneous) 2024 Q1 Medicine (miscellaneous) 2024 Q1 Engineering (miscellaneous) 2024 Q1 16.1 2024 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Besbinar, Omur Giro, Linda Bartoli, Mattia (orcid)0000-0002-4546-4111 Hueso, Jose L. Universidad de Zaragoza Mintz, Keenan J. Aydogan, Yagmur Garber, Jordan M. Turktas, Mine Ekim, Okan Ceylan, Ahmet Unal, Mehmet Altay Ensoy, Mine Ari, Fikret Ozgenç Çinar, Ozge Ozturk, Berfin Ilayda Gokce, Cemile Cansaran-Duman, Demet Braun, Markus Wachtveitl, Josef (orcid)0000-0002-8701-9745 Santamaria, Jesus Universidad de Zaragoza Delogu, Lucia Gemma Tagliaferro, Alberto Yilmazer, Açelya Leblanc, Roger M. 5005 555 Universidad de Zaragoza Dpto. Ing.Quím.Tecnol.Med.Amb. Área Ingeniería Química 5005 790 Universidad de Zaragoza Dpto. Ing.Quím.Tecnol.Med.Amb. Área Tecnologi. Medio Ambiente 20, 18 (2024), 2309283 [18 pp.] Small Small 1613-6810 3120138 http://zaguan.unizar.es/record/132136/files/texto_completo.pdf Postprint info:eu-repo/date/embargoEnd/2025-01-17 1743818 http://zaguan.unizar.es/record/132136/files/texto_completo.jpg?subformat=icon icon Postprint info:eu-repo/date/embargoEnd/2025-01-17 oai:zaguan.unizar.es:132136 articulos driver 2026-02-17-20:19:36 ARTICLE