132165 20260217205454.0 doi 10.3390/diagnostics14050492 sideral 137410 ART-2024-137410 eng Arias-Alvarez, Marta Retinal Function in Long-Term Type 1 Diabetes without Retinopathy: Insights from Pattern Electroretinogram and Pattern Visual Evoked Potentials Assessments 2024 Access copy available to the general public Unrestricted Background: To evaluate changes in pattern electroretinogram (pERG) and pattern visual evoked potentials (pVEP) in patients with long-lasting type 1 diabetes without diabetic retinopathy (DR). Methods: Prospective study involving 92 eyes divided into two groups. The diabetic group included 46 eyes of 23 patients with type 1 diabetes (T1DM); the control group included 23 age-matched healthy subjects. pERG and pVEP were assessed using the RETI-port/scan21 recording software (version 1021.3.0.0). Results: Mean age was 48 ± 9.77 years for the diabetic group and 51.7 ± 4.75 years for the control group. The mean duration of diabetes was 28.88 ± 8.04 years. The mean HbA1c value was 7.29 ± 0.89%. There were no differences in the age or sex distribution. Regarding the pERG, T1DM patients exhibited a significant decrease in the amplitude of the P50 and N95 waves compared to the control group (p = 0.018 and p = 0.035, respectively), with no differences in the peak time of each component. pVEP showed no significant changes in either peak time or amplitude of the different components. Conclusions: Long-term T1DM patients without DR showed changes in the amplitude of pERG waves with preserved peak times. We did not observe modifications in pVEP. pERG may serve as a subclinical marker of ganglion cell damage in long-term T1DM patients. info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI20-00740 info:eu-repo/semantics/openAccess by https://creativecommons.org/licenses/by/4.0/deed.es 3.3 2024 MEDICINE, GENERAL & INTERNAL 57 / 332 = 0.172 2024 Q1 T1 0.773 2024 Internal Medicine 2024 Q2 Clinical Biochemistry 2024 Q2 5.9 2024 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Sopeña-Pinilla, Maria Fernandez-Espinosa, Guisela Universidad de Zaragoza (orcid)0000-0003-1234-9712 Orduna-Hospital, Elvira Universidad de Zaragoza (orcid)0000-0003-2710-1875 Vicente-Garza, Ines Bonet-Rodriguez, Anna Acha-Perez, Javier (orcid)0000-0002-2987-6351 Rodriguez-Mena, Diego Universidad de Zaragoza Pinilla, Isabel Universidad de Zaragoza (orcid)0000-0003-0349-9997 1007 610 Universidad de Zaragoza Dpto. Medicina, Psiqu. y Derm. Area Medicina 1013 646 Universidad de Zaragoza Dpto. Cirugía Área Oftalmología 2002 647 Universidad de Zaragoza Dpto. Física Aplicada Área Óptica 14, 5 (2024), 492 [11 pp.] Diagnostics 2075-4418 615954 http://zaguan.unizar.es/record/132165/files/texto_completo.pdf Versión publicada 2710694 http://zaguan.unizar.es/record/132165/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:132165 articulos driver 2026-02-17-20:19:48 ARTICLE