000132169 001__ 132169
000132169 005__ 20250109150035.0
000132169 0247_ $$2doi$$a10.1109/TBME.2023.3300079
000132169 0248_ $$2sideral$$a137425
000132169 037__ $$aART-2023-137425
000132169 041__ $$aeng
000132169 100__ $$aHietakoste, Salla
000132169 245__ $$aAcute Cardiorespiratory Coupling Impairment in Worsening Sleep Apnea-Related Intermittent Hypoxemia
000132169 260__ $$c2023
000132169 5060_ $$aAccess copy available to the general public$$fUnrestricted
000132169 5203_ $$aObjective: Hypoxic load is one of the main characteristics of obstructive sleep apnea (OSA) contributing to sympathetic overdrive and weakened cardiorespiratory coupling (CRC). Whether this association changes with increasing hypoxic load has remained obscure. Therefore, we aimed to study our hypothesis that increasing hypoxic load acutely decreases the CRC. Methods: We retrospectively analyzed the electrocardiography and nasal pressure signals in 5-min segment pairs ( n = 36 926) recorded during clinical polysomnographies of 603 patients with suspected OSA. The segment pairs were pooled into five groups based on the hypoxic load severity described with the the total integrated area under the blood oxygen saturation curve during desaturations. In these severity groups, we determined the frequency-domain heart rate variability (HRV) parameters, the HRV and respiratory high-frequency (HF, 0.15–0.4 Hz) peaks, and the difference between those peaks. We also computed the spectral HF coherence between HRV and respiration in the HF band. Results: The ratio of low-frequency (LF, 0.04–0.15 Hz) to HF power increased from 1.047 to 1.805 ( p < 0.001); the difference between the HRV and respiratory HF peaks increased from 0.001 Hz to 0.039 Hz ( p < 0.001); and the spectral coherence between HRV and respiration in the HF band decreased from 0.813 to 0.689 ( p < 0.001) as the hypoxic load increased. Conclusion and Significance: The vagal modulation decreases and CRC weakens significantly with increasing hypoxic load. Thus, the hypoxic load could be utilized more thoroughly in contemporary OSA diagnostics to better assess the severity of OSA-related cardiac stress.
000132169 536__ $$9info:eu-repo/grantAgreement/ES/DGA-FSE/T39-20R-BSICoS group$$9info:eu-repo/grantAgreement/EC/H2020/965417/EU/Revolution of sleep diagnostics and personalized health care based on digital diagnostics and therapeutics with health data integration/SLEEP REVOLUTION$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 965417-SLEEP REVOLUTION$$9info:eu-repo/grantAgreement/ES/MCIU-AEI-FEDER/PID2021-126734OB-C21
000132169 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000132169 590__ $$a4.4$$b2023
000132169 592__ $$a1.239$$b2023
000132169 591__ $$aENGINEERING, BIOMEDICAL$$b36 / 123 = 0.293$$c2023$$dQ2$$eT1
000132169 593__ $$aBiomedical Engineering$$c2023$$dQ1
000132169 594__ $$a9.4$$b2023
000132169 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000132169 700__ $$0(orcid)0000-0001-5918-1043$$aArmañac-Julián, Pablo$$uUniversidad de Zaragoza
000132169 700__ $$aKarhu, Tuomas
000132169 700__ $$0(orcid)0000-0003-1272-0550$$aBailón, Raquel$$uUniversidad de Zaragoza
000132169 700__ $$aSillanmäki, Saara
000132169 700__ $$aTöyräs, Juha
000132169 700__ $$aLeppänen, Timo
000132169 700__ $$aMyllymaa, Sami
000132169 700__ $$aKainulainen, Samu
000132169 7102_ $$15008$$2800$$aUniversidad de Zaragoza$$bDpto. Ingeniería Electrón.Com.$$cÁrea Teoría Señal y Comunicac.
000132169 773__ $$g71, 1 (2023), 326-333$$pIEEE trans. biomed. eng.$$tIEEE Transactions on Biomedical Engineering$$x0018-9294
000132169 8564_ $$s2926895$$uhttps://zaguan.unizar.es/record/132169/files/texto_completo.pdf$$yVersión publicada
000132169 8564_ $$s3875653$$uhttps://zaguan.unizar.es/record/132169/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000132169 909CO $$ooai:zaguan.unizar.es:132169$$particulos$$pdriver
000132169 951__ $$a2025-01-09-14:59:07
000132169 980__ $$aARTICLE