132169 20250109150035.0 doi 10.1109/TBME.2023.3300079 sideral 137425 ART-2023-137425 eng Hietakoste, Salla Acute Cardiorespiratory Coupling Impairment in Worsening Sleep Apnea-Related Intermittent Hypoxemia 2023 Access copy available to the general public Unrestricted Objective: Hypoxic load is one of the main characteristics of obstructive sleep apnea (OSA) contributing to sympathetic overdrive and weakened cardiorespiratory coupling (CRC). Whether this association changes with increasing hypoxic load has remained obscure. Therefore, we aimed to study our hypothesis that increasing hypoxic load acutely decreases the CRC. Methods: We retrospectively analyzed the electrocardiography and nasal pressure signals in 5-min segment pairs ( n = 36 926) recorded during clinical polysomnographies of 603 patients with suspected OSA. The segment pairs were pooled into five groups based on the hypoxic load severity described with the the total integrated area under the blood oxygen saturation curve during desaturations. In these severity groups, we determined the frequency-domain heart rate variability (HRV) parameters, the HRV and respiratory high-frequency (HF, 0.15–0.4 Hz) peaks, and the difference between those peaks. We also computed the spectral HF coherence between HRV and respiration in the HF band. Results: The ratio of low-frequency (LF, 0.04–0.15 Hz) to HF power increased from 1.047 to 1.805 ( p < 0.001); the difference between the HRV and respiratory HF peaks increased from 0.001 Hz to 0.039 Hz ( p < 0.001); and the spectral coherence between HRV and respiration in the HF band decreased from 0.813 to 0.689 ( p < 0.001) as the hypoxic load increased. Conclusion and Significance: The vagal modulation decreases and CRC weakens significantly with increasing hypoxic load. Thus, the hypoxic load could be utilized more thoroughly in contemporary OSA diagnostics to better assess the severity of OSA-related cardiac stress. info:eu-repo/grantAgreement/ES/DGA-FSE/T39-20R-BSICoS group info:eu-repo/grantAgreement/EC/H2020/965417/EU/Revolution of sleep diagnostics and personalized health care based on digital diagnostics and therapeutics with health data integration/SLEEP REVOLUTION This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 965417-SLEEP REVOLUTION info:eu-repo/grantAgreement/ES/MCIU-AEI-FEDER/PID2021-126734OB-C21 info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 4.4 2023 ENGINEERING, BIOMEDICAL 36 / 123 = 0.293 2023 Q2 T1 1.239 2023 Biomedical Engineering 2023 Q1 9.4 2023 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Armañac-Julián, Pablo Universidad de Zaragoza (orcid)0000-0001-5918-1043 Karhu, Tuomas Bailón, Raquel Universidad de Zaragoza (orcid)0000-0003-1272-0550 Sillanmäki, Saara Töyräs, Juha Leppänen, Timo Myllymaa, Sami Kainulainen, Samu 5008 800 Universidad de Zaragoza Dpto. Ingeniería Electrón.Com. Área Teoría Señal y Comunicac. 71, 1 (2023), 326-333 IEEE trans. biomed. eng. IEEE Transactions on Biomedical Engineering 0018-9294 2926895 http://zaguan.unizar.es/record/132169/files/texto_completo.pdf Versión publicada 3875653 http://zaguan.unizar.es/record/132169/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:132169 articulos driver 2025-01-09-14:59:07 ARTICLE