132175 20260217205454.0 doi 10.1016/j.jff.2023.105936 sideral 137457 ART-2024-137457 eng Abad, I. Universidad de Zaragoza Does lactoferrin, free, encapsulated or in dairy matrices, maintain its antibacterial activity after in vitro digestion? 2024 Access copy available to the general public Unrestricted Milk is a source of active compounds with defensive properties, such as lactoferrin and milk fat globule membrane proteins. These proteins generate bioactive peptides in the gastrointestinal tract and it is known that industrial processing can modify their susceptibility to digestion. However, does lactoferrin maintain its antibacterial activity after passing through the gastrointestinal tract? The aim of this study was to evaluate the effect of technological treatments, encapsulation and in vitro digestion on lactoferrin antibacterial activity against Listeria monocytogenes. The results showed that the gastric digest of free lactoferrin presented greater effect against L. monocytogenes than the intestinal digest; although less than undigested lactoferrin. Alginate-lactoferrin microbeads allowed the release of lactoferrin into the intestine, protecting it from pepsin, although it was not sufficient to maintain its antibacterial activity to the intestine. However, homogenization and pasteurization favoured the antibacterial activity of dairy formulas supplemented with lactoferrin and of their digests. info:eu-repo/grantAgreement/ES/DGA/A20-23R info:eu-repo/grantAgreement/ES/MINECO/AGL2017-82987-R info:eu-repo/semantics/openAccess by-nc-nd https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es 4.0 2024 NUTRITION & DIETETICS 31 / 113 = 0.274 2024 Q2 T1 FOOD SCIENCE & TECHNOLOGY 56 / 182 = 0.308 2024 Q2 T1 0.837 2024 Food Science 2024 Q1 Nutrition and Dietetics 2024 Q2 Medicine (miscellaneous) 2024 Q2 6.9 2024 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Pemán, L. Pérez, M.D. Universidad de Zaragoza (orcid)0000-0003-2555-8425 Grasa, L. Universidad de Zaragoza (orcid)0000-0002-5306-9365 Sánchez, L. Universidad de Zaragoza (orcid)0000-0001-5964-823X 1012 410 Universidad de Zaragoza Dpto. Farmac.Fisiol.y Med.L.F. Área Fisiología 2008 780 Universidad de Zaragoza Dpto. Produc.Animal Cienc.Ali. Área Tecnología de Alimentos 112 (2024), 105936 [13 pp.] JOURNAL OF FUNCTIONAL FOODS Journal of Functional Foods 1756-4646 3408478 http://zaguan.unizar.es/record/132175/files/texto_completo.pdf Versión publicada 2623007 http://zaguan.unizar.es/record/132175/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:132175 articulos driver 2026-02-17-20:19:54 ARTICLE