000132275 001__ 132275
000132275 005__ 20240301161207.0
000132275 0247_ $$2doi$$a10.1016/j.tjnut.2023.12.001
000132275 0248_ $$2sideral$$a137465
000132275 037__ $$aART-2024-137465
000132275 041__ $$aeng
000132275 100__ $$aFloegel, Anna
000132275 245__ $$aCohort-based reference values for serum ferritin and transferrin and longitudinal determinants of iron status in European children aged 3–15 years
000132275 260__ $$c2024
000132275 5060_ $$aAccess copy available to the general public$$fUnrestricted
000132275 5203_ $$aBackground: Reference values of ferritin and transferrin for European children do not exist. Objective: We aimed to provide sex-, age-, and body mass index (BMI)-specific serum ferritin and transferrin reference percentiles of 3–15-y-old children based on cohort data and to investigate determinants of iron status. Methods: A total of 3390 ferritin and 3416 transferrin measurements from children residing in 8 European countries participating in the IDEFICS/I.Family cohort (https://www.isrctn.com/ISRCTN62310987) at baseline (W0) and 6 y later (W3) were used to estimate percentiles using the generalized additive model for location, scale and shape. Associations of serum ferritin and transferrin concentrations with total iron intake, total iron intake additionally adjusted for vitamin C intake, and iron from heme sources were investigated separately with adjustment for sex, age, country of residence, parental education, usual energy intake and BMI z-score in regression models using cross-sectional and longitudinal data. Results: The age-specific ferritin and transferrin 5th and 95th reference percentiles ranged from 10.9 to 81.1 μg/L and 2.23 to 3.56 g/L, respectively. A deficient iron status was observed in 3% of children at W0 and 7% of children and adolescents at W3, respectively. At both waves, a higher iron intake from heme sources was positively associated with serum ferritin {W0: β = 3.21 [95% confidence interval (CI): 0.71, 5.71]; W3: β = 4.48 [95% CI: 2.09, 6.87]}, that is, children consuming one mg more heme iron had a 3.21 and 4.48 μg/L higher ferritin concentration. Adherence to a mainly vegetarian diet was associated with a lower chance for sufficient serum ferritin cross-sectionally at W3 [odds ratio (OR) 0.40 (95% CI: 0.21, 0.81)] and longitudinally [OR 0.35 (95% CI: 0.15, 0.93)]. Conclusions: Age-, sex-, and BMI-specific reference percentiles of serum ferritin and transferrin concentrations based on cohort data are provided for European children aged 3–15 y and may be used in clinical practice.
000132275 536__ $$9info:eu-repo/grantAgreement/EUR/FP6/FOOD-016181$$9info:eu-repo/grantAgreement/EC/FP7/266044/EU/Determinants of eating behaviour in European children, adolescents and their parents/I.FAMILY
000132275 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000132275 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000132275 700__ $$aIntemann, Timm
000132275 700__ $$aSiani, Alfonso
000132275 700__ $$0(orcid)0000-0003-0454-653X$$aMoreno, Luis A.$$uUniversidad de Zaragoza
000132275 700__ $$aMolnár, Dénes
000132275 700__ $$aVeidebaum, Toomas
000132275 700__ $$aHadjigeorgiou, Charalambos
000132275 700__ $$aDe Henauw, Stefaan
000132275 700__ $$aHunsberger, Monica
000132275 700__ $$aEiben, Gabriele
000132275 700__ $$aAhrens, Wolfgang
000132275 700__ $$aWolters, Maike
000132275 7102_ $$11006$$2255$$aUniversidad de Zaragoza$$bDpto. Fisiatría y Enfermería$$cÁrea Enfermería
000132275 773__ $$g154, 2 (2024), 658-669$$pJ. nutr.$$tThe Journal of nutrition$$x0022-3166
000132275 8564_ $$s633143$$uhttps://zaguan.unizar.es/record/132275/files/texto_completo.pdf$$yVersión publicada
000132275 8564_ $$s2914085$$uhttps://zaguan.unizar.es/record/132275/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000132275 909CO $$ooai:zaguan.unizar.es:132275$$particulos$$pdriver
000132275 951__ $$a2024-03-01-14:53:46
000132275 980__ $$aARTICLE