000132277 001__ 132277
000132277 005__ 20240301161207.0
000132277 0247_ $$2doi$$a10.1016/j.exer.2023.109736
000132277 0248_ $$2sideral$$a137473
000132277 037__ $$aART-2024-137473
000132277 041__ $$aeng
000132277 100__ $$aRodrigo, M. J.
000132277 245__ $$aInfluence of sex on chronic steroid-induced glaucoma: 24-Weeks follow-up study in rats
000132277 260__ $$c2024
000132277 5203_ $$aThe objective was to evaluate ocular changes based on sex in steroid-induced glaucoma models in rats comparing healthy controls, over 24 weeks follow-up. Eighty-nine Long–Evans rats (38 males and 51 females) with steroid-induced glaucoma were analysed. Two steroid-induced glaucoma models were generated by injecting poly-co-lactic-glycolic acid microspheres loaded with dexamethasone (MMDEX model) and dexamethasone-fibronectin (MMDEXAFIBRO model) into the ocular anterior chamber. Intraocular pressure was measured by rebound tonometer Tonolab®. Neuroretinal function was analysed using dark- and light-adapted electroretinography (Roland consult® RETIanimal ERG), and structure was analysed using optical coherence tomography (OCT Spectralis, Heidelberg® Engineering) using Retina Posterior Pole, Retinal Nerve Fibre Layer and Ganglion Cell Layer protocols over 24 weeks. Males showed statistically (p < 0.05) higher intraocular pressure measurements. In both sexes and models neuroretinal thickness tended to decrease over time. In the MMDEX model, males showed higher IOP values and greatest percentage thickness loss in the Ganglion Cell Layer (p = 0.015). Females receiving MMDEXAFIBRO experienced large fluctuations in thickness, a higher percentage loss (on average) in Retina Posterior Pole (p = 0.035), Retinal Nerve Fibre Layer and Ganglion Cell Layer than aged-matched males, and the highest thickness loss rate by mmHg. Although no difference was found by sex in dark- and light-adapted electroretinography, increased amplitude in photopic negative response was found in MMDEX males and MMDEXAFIBRO females at 12 weeks. Although both glaucoma models used dexamethasone, different intraocular pressure and neuroretinal changes were observed depending on sex and other influential cofactors (fibronectin). Both sex and the induced glaucoma model influenced neuroretinal degeneration.
000132277 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI17-01726$$9info:eu-repo/grantAgreement/ES/ISCIII-FEDER-RETICS/RD16-0008-0004$$9info:eu-repo/grantAgreement/ES/ISCIII-FEDER-RETICS/RD16-0008-0009$$9info:eu-repo/grantAgreement/ES/ISCIII/M17-00213$$9info:eu-repo/grantAgreement/ES/ISCIII/PI17-01946$$9info:eu-repo/grantAgreement/ES/ISCIII/RETICS-RD16-0008-029$$9info:eu-repo/grantAgreement/ES/MICINN/MAT2017-83858-C2-1$$9info:eu-repo/grantAgreement/ES/MICINN/MAT2017-83858-C2-2
000132277 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000132277 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000132277 700__ $$aMartinez-Rincon, T.$$uUniversidad de Zaragoza
000132277 700__ $$aSubias, M.$$uUniversidad de Zaragoza
000132277 700__ $$0(orcid)0000-0001-6072-1545$$aMendez-Martinez, S.
000132277 700__ $$aGarcia-Herranz, D.
000132277 700__ $$aGarcia-Feijoo, J.
000132277 700__ $$aHerrero-Vanrell, R.
000132277 700__ $$0(orcid)0000-0003-2389-8282$$aPablo, L.$$uUniversidad de Zaragoza
000132277 700__ $$aBravo-Osuna, I.
000132277 700__ $$aMunuera, I.
000132277 700__ $$0(orcid)0000-0001-6258-2489$$aGarcía-Martin, E.$$uUniversidad de Zaragoza
000132277 7102_ $$11013$$2645$$aUniversidad de Zaragoza$$bDpto. Cirugía$$cÁrea Obstetricia y Ginecología
000132277 7102_ $$11013$$2646$$aUniversidad de Zaragoza$$bDpto. Cirugía$$cÁrea Oftalmología
000132277 773__ $$g238 (2024), 109736 [11 pp.]$$pExp. Eye Res.$$tExperimental Eye Research$$x0014-4835
000132277 8564_ $$s7472915$$uhttps://zaguan.unizar.es/record/132277/files/texto_completo.pdf$$yVersión publicada
000132277 8564_ $$s2384565$$uhttps://zaguan.unizar.es/record/132277/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000132277 909CO $$ooai:zaguan.unizar.es:132277$$particulos$$pdriver
000132277 951__ $$a2024-03-01-14:53:48
000132277 980__ $$aARTICLE