132288 20241125101154.0 doi 10.3389/fphys.2023.1189464 sideral 137382 ART-2023-137382 eng Celotto, Chiara Universidad de Zaragoza The frequency of atrial fibrillatory waves is modulated by the spatiotemporal pattern of acetylcholine release: a 3D computational study 2023 Access copy available to the general public Unrestricted In atrial fibrillation (AF), the ECG P-wave, which represents atrial depolarization, is replaced with chaotic and irregular fibrillation waves (f waves). The f-wave frequency, Ff, shows significant variations over time. Cardiorespiratory interactions regulated by the autonomic nervous system have been suggested to play a role in such variations. We conducted a simulation study to test whether the spatiotemporal release pattern of the parasympathetic neurotransmitter acetylcholine (ACh) modulates the frequency of atrial reentrant circuits. Understanding parasympathetic involvement in AF may guide more effective treatment approaches and could help to design autonomic markers alternative to heart rate variability (HRV), which is not available in AF patients. 2D tissue and 3D whole-atria models of human atrial electrophysiology in persistent AF were built. Different ACh release percentages (8% and 30%) and spatial ACh release patterns, including spatially random release and release from ganglionated plexi (GPs) and associated nerves, were considered. The temporal pattern of ACh release, ACh(t), was simulated following a sinusoidal waveform of frequency 0.125 Hz to represent the respiratory frequency. Different mean concentrations (ACh̄) and peak-to-peak ranges of ACh (ΔACh) were tested. We found that temporal variations in Ff, Ff(t), followed the simulated temporal ACh(t) pattern in all cases. The temporal mean of Ff(t), F̄f, depended on the fibrillatory pattern (number and location of rotors), the percentage of ACh release nodes and ACh̄. The magnitude of Ff(t) modulation, ΔFf, depended on the percentage of ACh release nodes and ΔACh. The spatial pattern of ACh release did not have an impact on F̄f and only a mild impact on ΔFf. The f-wave frequency, being indicative of vagal activity, has the potential to drive autonomic-based therapeutic actions and could replace HRV markers not quantifiable from AF patients. info:eu-repo/grantAgreement/ES/DGA/LMP141-21 info:eu-repo/grantAgreement/ES/DGA/LMP94_21 info:eu-repo/grantAgreement/ES/DGA/T39-23R info:eu-repo/grantAgreement/EC/H2020/766082/EU/MultidisciplinarY training network for ATrial fibRillation monItoring, treAtment and progression/MY-ATRIA This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 766082-MY-ATRIA info:eu-repo/grantAgreement/ES/MICINN/PID2019-104881RB-I00 info:eu-repo/grantAgreement/ES/MICINN/PID2019-105674RB-I00 info:eu-repo/grantAgreement/ES/MICINN/PID2022-140556OB-I00 info:eu-repo/grantAgreement/EUR/MICINN/TED2021-130459B-I00 info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 3.2 2023 PHYSIOLOGY 24 / 85 = 0.282 2023 Q2 T1 1.006 2023 Physiology (medical) 2023 Q2 Physiology 2023 Q2 6.5 2023 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Sánchez, Carlos Universidad de Zaragoza (orcid)0000-0003-4273-5403 Abdollahpur, Mostafa Sandberg, Frida Rodriguez Matas, Jose F. Laguna, Pablo Universidad de Zaragoza (orcid)0000-0003-3434-9254 Pueyo, Esther Universidad de Zaragoza (orcid)0000-0002-1960-407X 5007 520 Universidad de Zaragoza Dpto. Informát.Ingenie.Sistms. Área Ingen.Sistemas y Automát. 5008 800 Universidad de Zaragoza Dpto. Ingeniería Electrón.Com. Área Teoría Señal y Comunicac. 14 (2023), [18 pp.] Front. physiol. Frontiers in physiology 1664-042X 668505 http://zaguan.unizar.es/record/132288/files/texto_completo.pdf Versión publicada 2266559 http://zaguan.unizar.es/record/132288/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:132288 articulos driver 2024-11-22-12:08:27 ARTICLE