132290 20241125101154.0 doi 10.1016/j.mtbio.2023.100935 sideral 137403 ART-2023-137403 eng Rodrigo, María J. Universidad de Zaragoza Laponite for biomedical applications: An ophthalmological perspective 2023 Access copy available to the general public Unrestricted Clay minerals have been applied in biomedicine for thousands of years. Laponite is a nanostructured synthetic clay with the capacity to retain and progressively release drugs. In recent years there has been a resurgence of interest in Laponite application in various biomedical areas. This is the first paper to review the potential biomedical applications of Laponite in ophthalmology. The introduction briefly covers the physical, chemical, rheological, and biocompatibility features of different routes of administration. After that, emphasis is placed on 1) drug delivery for antibiotics, anti-inflammatories, growth factors, other proteins, and cancer treatment; 2) bleeding prevention or treatment; and 3) tissue engineering through regenerative medicine using scaffolds in intraocular and extraocular tissue. Although most scientific research is not performed on the eye, both the findings and the new treatments resulting from that research are potentially applicable in ophthalmology since many of the drugs used are the same, the tissue evaluated in vitro or in vivo is also present in the eye, and the pathologies treated also occur in the eye. Finally, future prospects for this emerging field are discussed. info:eu-repo/grantAgreement/ES/ISCIII/JR22-00057 info:eu-repo/grantAgreement/ES/ISCIII/M17-00213 info:eu-repo/grantAgreement/ES/ISCIII/PI17-01726 info:eu-repo/grantAgreement/ES/ISCIII/PI17-01946 info:eu-repo/grantAgreement/ES/ISCIII/PI20-00437 info:eu-repo/grantAgreement/ES/MICINN/MAT2017-83858-C2-1 info:eu-repo/grantAgreement/ES/MICINN/MAT2017-83858-C2-2 info:eu-repo/grantAgreement/ES/MICINN/PID2020-113281RB-C21 info:eu-repo/grantAgreement/ES/MICINN/PID2020-113281RB-C22 info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 8.7 2023 MATERIALS SCIENCE, BIOMATERIALS 6 / 53 = 0.113 2023 Q1 T1 ENGINEERING, BIOMEDICAL 11 / 123 = 0.089 2023 Q1 T1 1.518 2023 Bioengineering 2023 Q1 Biomaterials 2023 Q1 Molecular Biology 2023 Q1 Biotechnology 2023 Q1 Biomedical Engineering 2023 Q1 Cell Biology 2023 Q2 8.3 2023 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Cardiel, María J. Universidad de Zaragoza (orcid)0000-0002-7914-4685 Fraile, José M. (orcid)0000-0002-0136-5138 Mayoral, José A. Universidad de Zaragoza (orcid)0000-0003-1570-4257 Pablo, Luis E. Universidad de Zaragoza (orcid)0000-0003-2389-8282 García-Martin, Elena Universidad de Zaragoza (orcid)0000-0001-6258-2489 2013 765 Universidad de Zaragoza Dpto. Química Orgánica Área Química Orgánica 1013 646 Universidad de Zaragoza Dpto. Cirugía Área Oftalmología 1013 020 Universidad de Zaragoza Dpto. Cirugía Área Anatomía Patológica 24 (2023), 100935 [14 pp.] Materials Today Bio 2590-0064 4515183 http://zaguan.unizar.es/record/132290/files/texto_completo.pdf Versión publicada 2673324 http://zaguan.unizar.es/record/132290/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:132290 articulos driver 2024-11-22-12:08:29 ARTICLE