000132291 001__ 132291
000132291 005__ 20241125101154.0
000132291 0247_ $$2doi$$a10.1093/gerona/glad216
000132291 0248_ $$2sideral$$a137471
000132291 037__ $$aART-2023-137471
000132291 041__ $$aeng
000132291 100__ $$aZapater-Fajarí, Mariola
000132291 245__ $$aBiomarkers of Alzheimer’s Disease and Cerebrovascular Disease in Relation to Depressive Symptomatology in Individuals With Subjective Cognitive Decline
000132291 260__ $$c2023
000132291 5060_ $$aAccess copy available to the general public$$fUnrestricted
000132291 5203_ $$aBackground :Subjective cognitive decline (SCD) has gained recent interest as a potential harbinger of neurodegenerative diseases such as Alzheimer’s disease (AD) and cerebrovascular disease (CVD). In addition, SCD can be related to depressive symptomatology. However, the association between AD and CVD biomarkers, depressive symptomatology, and SCD is still unclear. We investigated the association of AD and CVD biomarkers and depressive symptomatology with SCD in individuals with subjective memory complaints (SCD-memory group) and individuals with subjective concentration complaints (SCD-concentration group).
Methods:We recruited a population-based cohort of 217 individuals (all aged 70 years, 53% female participants, 119 SCD-memory individuals, 23 SCD-concentration individuals, and 89 controls). AD and CVD were assessed through cerebrospinal fluid levels of the Aβ42/40 ratio and phosphorylated tau, and white matter signal abnormalities on magnetic resonance imaging, respectively. Associations between biomarkers, depressive symptomatology, and SCD were tested via logistic regression and correlation analyses.
Results: We found a significant association between depressive symptomatology with SCD-memory and SCD-concentration. Depressive symptomatology was not associated with AD and CVD biomarkers. Both the phosphorylated tau biomarker and depressive symptomatology predicted SCD-memory, and the Aβ42/40 ratio and depressive symptomatology predicted SCD-concentration.
Conclusions:The role of depressive symptomatology in SCD may differ depending on the stage within the spectrum of preclinical AD (as determined by amyloid-beta and tau positivity), and does not seem to reflect AD pathology. Our findings contribute to the emerging field of subclinical depressive symptomatology in SCD and clarify the association of different types of subjective complaints with distinct syndromic and biomarker profiles.
000132291 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000132291 590__ $$a4.3$$b2023
000132291 592__ $$a1.285$$b2023
000132291 591__ $$aGERONTOLOGY$$b7 / 47 = 0.149$$c2023$$dQ1$$eT1
000132291 593__ $$aGeriatrics and Gerontology$$c2023$$dQ1
000132291 591__ $$aGERIATRICS & GERONTOLOGY$$b18 / 74 = 0.243$$c2023$$dQ1$$eT1
000132291 593__ $$aAging$$c2023$$dQ2
000132291 594__ $$a10.0$$b2023
000132291 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000132291 700__ $$aDiaz-Galvan, Patricia
000132291 700__ $$aCedres, Nira
000132291 700__ $$aRydberg Sterner, Therese
000132291 700__ $$aRydén, Lina
000132291 700__ $$aSacuiu, Simona
000132291 700__ $$aWaern, Margda
000132291 700__ $$aZettergren, Anna
000132291 700__ $$aZetterberg, Henrik
000132291 700__ $$aBlennow, Kaj
000132291 700__ $$aKern, Silke
000132291 700__ $$0(orcid)0000-0003-3920-1099$$aHidalgo, Vanesa$$uUniversidad de Zaragoza
000132291 700__ $$aSalvador, Alicia
000132291 700__ $$aWestman, Eric
000132291 700__ $$aSkoog, Ingmar
000132291 700__ $$aFerreira, Daniel
000132291 7102_ $$14009$$2725$$aUniversidad de Zaragoza$$bDpto. Psicología y Sociología$$cÁrea Psicobiología
000132291 773__ $$g79, 2 (2023), 11 pp.$$pJ. gerontol., Ser. A, biol. sci. med. sci.$$tThe journals of gerontology. Series A, Biological sciences and medical sciences$$x1079-5006
000132291 8564_ $$s409926$$uhttps://zaguan.unizar.es/record/132291/files/texto_completo.pdf$$yVersión publicada
000132291 8564_ $$s2997328$$uhttps://zaguan.unizar.es/record/132291/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000132291 909CO $$ooai:zaguan.unizar.es:132291$$particulos$$pdriver
000132291 951__ $$a2024-11-22-12:08:29
000132291 980__ $$aARTICLE