000132315 001__ 132315
000132315 005__ 20240711085512.0
000132315 0247_ $$2doi$$a10.1093/nar/gkae051
000132315 0248_ $$2sideral$$a137395
000132315 037__ $$aART-2024-137395
000132315 041__ $$aeng
000132315 100__ $$0(orcid)0000-0003-1885-4365$$aOrtega-Alarcón, David
000132315 245__ $$aExtending MeCP2 interactome: canonical nucleosomal histones interact with MeCP2
000132315 260__ $$c2024
000132315 5060_ $$aAccess copy available to the general public$$fUnrestricted
000132315 5203_ $$aMeCP2 is a general regulator of transcription involved in the repression/activation of genes depending on the local epigenetic context. It acts as a chromatin regulator and binds with exquisite specificity to gene promoters. The set of epigenetic marks recognized by MeCP2 has been already established (mainly, cytosine modifications in CpG and CpA), as well as many of the constituents of its interactome. We unveil a new set of interactions for MeCP2 with the four canonical nucleosomal histones. MeCP2 interacts with high affinity with H2A, H2B, H3 and H4. In addition, Rett syndrome associated mutations in MeCP2 and histone epigenetic marks modulate these interactions. Given the abundance and the structural/functional relevance of histones and their involvement in epigenetic regulation, this new set of interactions and its modulating elements provide a new addition to the ‘alphabet’ for this epigenetic reader.
000132315 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII/PI21-00394$$9info:eu-repo/grantAgreement/ES/MCIU-AEI-FEDER/BES-2017-080739$$9info:eu-repo/grantAgreement/ES/MCIU-AEI-FEDER/BFU2016-78232-P$$9info:eu-repo/grantAgreement/ES/MICINN/AEI/PID2021-127296OB-I00$$9info:eu-repo/grantAgreement/ES/MICINN-AEI/PRTR-C17.I1
000132315 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc$$uhttp://creativecommons.org/licenses/by-nc/3.0/es/
000132315 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000132315 700__ $$aClaveria-Gimeno, Rafael
000132315 700__ $$0(orcid)0000-0002-1232-6310$$aVega, Sonia
000132315 700__ $$aKalani, Ladan
000132315 700__ $$aJorge-Torres, Olga C
000132315 700__ $$aEsteller, Manel
000132315 700__ $$aAusio, Juan
000132315 700__ $$0(orcid)0000-0001-5664-1729$$aAbian, Olga$$uUniversidad de Zaragoza
000132315 700__ $$0(orcid)0000-0001-5702-4538$$aVelázquez-Campoy, Adrián$$uUniversidad de Zaragoza
000132315 7102_ $$11002$$2060$$aUniversidad de Zaragoza$$bDpto. Bioq.Biolog.Mol. Celular$$cÁrea Bioquímica y Biolog.Mole.
000132315 773__ $$g52, 7 (2024), 3636–3653$$pNucleic acids res.$$tNucleic Acids Research$$x0305-1048
000132315 8564_ $$s3583064$$uhttps://zaguan.unizar.es/record/132315/files/texto_completo.pdf$$yVersión publicada
000132315 8564_ $$s2381838$$uhttps://zaguan.unizar.es/record/132315/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000132315 909CO $$ooai:zaguan.unizar.es:132315$$particulos$$pdriver
000132315 951__ $$a2024-07-11-08:52:29
000132315 980__ $$aARTICLE