132315 20260217205509.0 doi 10.1093/nar/gkae051 sideral 137395 ART-2024-137395 eng Ortega-Alarcón, David (orcid)0000-0003-1885-4365 Extending MeCP2 interactome: canonical nucleosomal histones interact with MeCP2 2024 Access copy available to the general public Unrestricted MeCP2 is a general regulator of transcription involved in the repression/activation of genes depending on the local epigenetic context. It acts as a chromatin regulator and binds with exquisite specificity to gene promoters. The set of epigenetic marks recognized by MeCP2 has been already established (mainly, cytosine modifications in CpG and CpA), as well as many of the constituents of its interactome. We unveil a new set of interactions for MeCP2 with the four canonical nucleosomal histones. MeCP2 interacts with high affinity with H2A, H2B, H3 and H4. In addition, Rett syndrome associated mutations in MeCP2 and histone epigenetic marks modulate these interactions. Given the abundance and the structural/functional relevance of histones and their involvement in epigenetic regulation, this new set of interactions and its modulating elements provide a new addition to the ‘alphabet’ for this epigenetic reader. info:eu-repo/grantAgreement/ES/ISCIII/PI21-00394 info:eu-repo/grantAgreement/ES/MCIU-AEI-FEDER/BES-2017-080739 info:eu-repo/grantAgreement/ES/MCIU-AEI-FEDER/BFU2016-78232-P info:eu-repo/grantAgreement/ES/MICINN/AEI/PID2021-127296OB-I00 info:eu-repo/grantAgreement/ES/MICINN-AEI/PRTR-C17.I1 info:eu-repo/semantics/openAccess by-nc https://creativecommons.org/licenses/by-nc/4.0/deed.es 13.1 2024 BIOCHEMISTRY & MOLECULAR BIOLOGY 13 / 320 = 0.041 2024 Q1 T1 7.776 2024 Genetics 2024 Q1 31.7 2024 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Claveria-Gimeno, Rafael Vega, Sonia (orcid)0000-0002-1232-6310 Kalani, Ladan Jorge-Torres, Olga C Esteller, Manel Ausio, Juan Abian, Olga Universidad de Zaragoza (orcid)0000-0001-5664-1729 Velázquez-Campoy, Adrián Universidad de Zaragoza (orcid)0000-0001-5702-4538 1002 060 Universidad de Zaragoza Dpto. Bioq.Biolog.Mol. Celular Área Bioquímica y Biolog.Mole. 52, 7 (2024), 3636–3653 Nucleic acids res. Nucleic Acids Research 0305-1048 3583064 http://zaguan.unizar.es/record/132315/files/texto_completo.pdf Versión publicada 2381838 http://zaguan.unizar.es/record/132315/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:132315 articulos driver 2026-02-17-20:24:42 ARTICLE