000132336 001__ 132336
000132336 005__ 20240711085513.0
000132336 0247_ $$2doi$$a10.1007/s00431-024-05435-4
000132336 0248_ $$2sideral$$a137275
000132336 037__ $$aART-2024-137275
000132336 041__ $$aeng
000132336 100__ $$0(orcid)0000-0003-3435-4854$$aPérez-Gimeno, Gloria
000132336 245__ $$aInterplay of the Mediterranean diet and genetic hypertension risk on blood pressure in European adolescents: Findings from the HELENA study
000132336 260__ $$c2024
000132336 5060_ $$aAccess copy available to the general public$$fUnrestricted
000132336 5203_ $$aEarly-life onset of high blood pressure is associated with the development of cardiovascular diseases in adulthood. In adolescents, limited evidence exists regarding the association between adherence to the Mediterranean Diet (MedDiet) and normal blood pressure (BP) levels, as well as its potential to modulate genetic predisposition to HTN. This study investigated the interaction between a MedDiet score and a recently developed HTN-genetic risk score (HTN-GRS) on blood pressure levels in a European adolescent cohort. The MedDiet score was derived from two non-consecutive 24-h dietary recalls and ranged from 0 (indicating low adherence) to 9 (indicating high adherence). Multiple linear regression models, adjusted for covariates, were employed to examine the relationship between the MedDiet score and BP z-scores and to assess the interaction effects between the MedDiet score and HTN-GRS on BP z-scores. MedDiet score showed a negative association with z-systolic BP (SBP) (ß = −0.40, p < 0.001) and z-diastolic BP (DBP) (ß = −0.29, p = 0.001). Additionally, a significant interaction effect was identified between the MedDiet score and HTN-GRS on z-SBP (ß = 0.02, p < 0.001) and z-DBP (ß = 0.02, p < 0.001). The modulatory effect of the MedDiet was more pronounced in females than in males, and HTN-GRS exhibited a stronger influence on DBP than on SBP.
Conclusion: The study suggests that higher adherence to the MedDiet is associated with reduced BP levels in adolescents and provides evidence of a genetic-diet interaction influencing BP in adolescents.
000132336 536__ $$9info:eu-repo/grantAgreement/EUR/FP6/FOODCT-2005-007034$$9info:eu-repo/grantAgreement/EC/H2020/801586/EU/International Doctoral Programme for Talent Attraction to the Campus of International Excellence of the Ebro Valley/IberusTalent$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 801586-IberusTalent
000132336 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000132336 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000132336 700__ $$0(orcid)0000-0001-6899-5938$$aSeral-Cortés, Miguel$$uUniversidad de Zaragoza
000132336 700__ $$aSabroso-Lasa, Sergio
000132336 700__ $$0(orcid)0000-0002-3007-302X$$aEsteban, Luis Mariano
000132336 700__ $$aWidhalm, Kurt
000132336 700__ $$aGottrand, Frederic
000132336 700__ $$aStehle, Peter
000132336 700__ $$aMeirhaeghe, Aline
000132336 700__ $$aMuntaner, Manon
000132336 700__ $$aKafatos, Anthony
000132336 700__ $$aGutierrez, Angel
000132336 700__ $$aManios, Yannis
000132336 700__ $$aAnastasiou, Costas A.
000132336 700__ $$aGonzalez-Gross, Marcela
000132336 700__ $$aBreidenassel, Christina
000132336 700__ $$aCensi, Laura
000132336 700__ $$ade Henauw, Stefaan
000132336 700__ $$aLabayen, Idoia
000132336 700__ $$0(orcid)0000-0002-0902-387X$$aBueno-Lozano, Gloria$$uUniversidad de Zaragoza
000132336 700__ $$0(orcid)0000-0002-3850-8235$$aRupérez, Azahara I.
000132336 700__ $$0(orcid)0000-0003-0454-653X$$aMoreno, Luis A.$$uUniversidad de Zaragoza
000132336 7102_ $$11006$$2255$$aUniversidad de Zaragoza$$bDpto. Fisiatría y Enfermería$$cÁrea Enfermería
000132336 7102_ $$11011$$2670$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Pediatría
000132336 773__ $$g183 (2024), 2101–2110$$pEur. j. pediatr.$$tEuropean Journal of Pediatrics$$x0340-6199
000132336 8564_ $$s1279618$$uhttps://zaguan.unizar.es/record/132336/files/texto_completo.pdf$$yVersión publicada
000132336 8564_ $$s1958548$$uhttps://zaguan.unizar.es/record/132336/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000132336 909CO $$ooai:zaguan.unizar.es:132336$$particulos$$pdriver
000132336 951__ $$a2024-07-11-08:52:31
000132336 980__ $$aARTICLE