132336 20260217205515.0 doi 10.1007/s00431-024-05435-4 sideral 137275 ART-2024-137275 eng Pérez-Gimeno, Gloria (orcid)0000-0003-3435-4854 Interplay of the Mediterranean diet and genetic hypertension risk on blood pressure in European adolescents: Findings from the HELENA study 2024 Access copy available to the general public Unrestricted Early-life onset of high blood pressure is associated with the development of cardiovascular diseases in adulthood. In adolescents, limited evidence exists regarding the association between adherence to the Mediterranean Diet (MedDiet) and normal blood pressure (BP) levels, as well as its potential to modulate genetic predisposition to HTN. This study investigated the interaction between a MedDiet score and a recently developed HTN-genetic risk score (HTN-GRS) on blood pressure levels in a European adolescent cohort. The MedDiet score was derived from two non-consecutive 24-h dietary recalls and ranged from 0 (indicating low adherence) to 9 (indicating high adherence). Multiple linear regression models, adjusted for covariates, were employed to examine the relationship between the MedDiet score and BP z-scores and to assess the interaction effects between the MedDiet score and HTN-GRS on BP z-scores. MedDiet score showed a negative association with z-systolic BP (SBP) (ß = −0.40, p < 0.001) and z-diastolic BP (DBP) (ß = −0.29, p = 0.001). Additionally, a significant interaction effect was identified between the MedDiet score and HTN-GRS on z-SBP (ß = 0.02, p < 0.001) and z-DBP (ß = 0.02, p < 0.001). The modulatory effect of the MedDiet was more pronounced in females than in males, and HTN-GRS exhibited a stronger influence on DBP than on SBP. Conclusion: The study suggests that higher adherence to the MedDiet is associated with reduced BP levels in adolescents and provides evidence of a genetic-diet interaction influencing BP in adolescents. info:eu-repo/grantAgreement/EUR/FP6/FOODCT-2005-007034 info:eu-repo/grantAgreement/EC/H2020/801586/EU/International Doctoral Programme for Talent Attraction to the Campus of International Excellence of the Ebro Valley/IberusTalent This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 801586-IberusTalent info:eu-repo/semantics/openAccess by https://creativecommons.org/licenses/by/4.0/deed.es 2.6 2024 PEDIATRICS 37 / 191 = 0.194 2024 Q1 T1 0.934 2024 Pediatrics, Perinatology and Child Health 2024 Q1 5.9 2024 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Seral-Cortés, Miguel Universidad de Zaragoza (orcid)0000-0001-6899-5938 Sabroso-Lasa, Sergio Esteban, Luis Mariano (orcid)0000-0002-3007-302X Widhalm, Kurt Gottrand, Frederic Stehle, Peter Meirhaeghe, Aline Muntaner, Manon Kafatos, Anthony Gutierrez, Angel Manios, Yannis Anastasiou, Costas A. Gonzalez-Gross, Marcela Breidenassel, Christina Censi, Laura de Henauw, Stefaan Labayen, Idoia Bueno-Lozano, Gloria Universidad de Zaragoza (orcid)0000-0002-0902-387X Rupérez, Azahara I. (orcid)0000-0002-3850-8235 Moreno, Luis A. Universidad de Zaragoza (orcid)0000-0003-0454-653X 1006 255 Universidad de Zaragoza Dpto. Fisiatría y Enfermería Área Enfermería 1011 670 Universidad de Zaragoza Dpto. Microb.Ped.Radio.Sal.Pú. Área Pediatría 183 (2024), 2101–2110 Eur. j. pediatr. European Journal of Pediatrics 0340-6199 1279618 http://zaguan.unizar.es/record/132336/files/texto_completo.pdf Versión publicada 1958548 http://zaguan.unizar.es/record/132336/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:132336 articulos driver 2026-02-17-20:26:50 ARTICLE