132377 20240311111224.0 doi 10.3233/JAE-209118 sideral 119226 ART-2020-119226 eng López-Alonso, Borja Universidad de Zaragoza (orcid)0000-0003-2848-170X Electro-thermal modeling of irreversible electroporation and validation method of electric field distribution 2020 Nowadays, several applications of electroporation have been adopted in cancer therapy with promising results that have boosted research interest. To develop new treatment options, the development of electroporation models and measurement method in order to study the real distribution of the electric field potential are needed. Nowadays, current trends in electroporation techniques suggest the use of more powerful pulse generators that enables the treatment of larger tissue volumes. However, new challenges arise regarding the modeling of the electroporation process in large tissue volumes as well as the potential thermal effects when large amounts of energy are used. The aim of this paper is to propose a finite element analysis (FEA) based model using COMSOL of the irreversible electroporation process considering both electrical and thermal effects, and to validate it through in-vivo experimentation. Moreover, we propose a methodology for measuring the electrical potential in different points of a biological tissue during the application of a train of pulses to measure the distribution of the electric field inside the tissue. For this application, needle-based electrodes have been developed to achieve the least invasive measurement possible. These tools are aimed to improve the application of the electroporation treatment by reducing its side effects. Access copy available to the general public Unrestricted info:eu-repo/grantAgreement/ES/DGA/LMP106-18 info:eu-repo/grantAgreement/ES/MECD/FPU16-03765 info:eu-repo/grantAgreement/ES/MINECO/RTC-2017-5965-6 info:eu-repo/grantAgreement/ES/MINECO/TEC2016-78358-R info:eu-repo/semantics/openAccess All rights reserved http://www.europeana.eu/rights/rr-f/ 0.706 2020 ENGINEERING, ELECTRICAL & ELECTRONIC 256 / 273 = 0.938 2020 Q4 T3 PHYSICS, APPLIED 153 / 160 = 0.956 2020 Q4 T3 MECHANICS 127 / 135 = 0.941 2020 Q4 T3 0.238 2020 Electrical and Electronic Engineering 2020 Q3 Electronic, Optical and Magnetic Materials 2020 Q3 Mechanics of Materials 2020 Q3 Mechanical Engineering 2020 Q3 Condensed Matter Physics 2020 Q3 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Sarnago, Héctor Universidad de Zaragoza (orcid)0000-0001-8399-4650 Burdío, Jose Miguel Universidad de Zaragoza (orcid)0000-0002-9655-5531 Lucía, Óscar Universidad de Zaragoza (orcid)0000-0002-1284-9007 5008 785 Universidad de Zaragoza Dpto. Ingeniería Electrón.Com. Área Tecnología Electrónica 63, S1 (2020), S41-S50 Int. j. appl. electromagn. mech. International journal of applied electromagnetics and mechanics 1383-5416 880934 http://zaguan.unizar.es/record/132377/files/texto_completo.pdf Postprint 1312268 http://zaguan.unizar.es/record/132377/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:132377 articulos driver 2024-03-11-09:48:54 ARTICLE