000132378 001__ 132378 000132378 005__ 20240311111224.0 000132378 0247_ $$2doi$$a10.1109/TBME.2019.2928645 000132378 0248_ $$2sideral$$a117864 000132378 037__ $$aART-2020-117864 000132378 041__ $$aeng 000132378 100__ $$aGarcia-Sanchez, T. 000132378 245__ $$aSuccessful Tumor Electrochemotherapy Using Sine Waves 000132378 260__ $$c2020 000132378 5060_ $$aAccess copy available to the general public$$fUnrestricted 000132378 5203_ $$aObjective: The purpose of this work is to assess the ability of sine waves to perform electrochemotherapy (ECT) and to study the dependence of the frequency of the applied sine wave on the treatment efficacy. Methods: A subcutaneous tumor model in mice was used, and the electric field was delivered in combination with bleomycin. Sinusoidal electric fields of different frequencies, amplitudes, and durations were compared to square waves. Computer simulations were additionally performed. Results: The results confirmed the ability of a sinusoidal electric field to obtain successful ECT responses. A strong dependence on frequency was obtained. The efficacy of the treatment decreased when the frequency of the sine waves was increased. At low sinusoidal frequency, the efficacy of the treatment is very similar to that obtained with a square wave. The collateral effects such as skin burns and muscle contractions decreased for the highest frequency assayed. Conclusion: The use of sine wave burst represents a feasible option for the treatment of cancer by ECT. Significance: These results could have important implications for the treatment of cancer in the clinical world where ECT is performed with dc square pulses. 000132378 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/ 000132378 590__ $$a4.538$$b2020 000132378 591__ $$aENGINEERING, BIOMEDICAL$$b24 / 89 = 0.27$$c2020$$dQ2$$eT1 000132378 592__ $$a1.147$$b2020 000132378 593__ $$aBiomedical Engineering$$c2020$$dQ1 000132378 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion 000132378 700__ $$aMercadal, B. 000132378 700__ $$aPolrot, M. 000132378 700__ $$aMuscat, A. 000132378 700__ $$0(orcid)0000-0001-8399-4650$$aSarnago, H.$$uUniversidad de Zaragoza 000132378 700__ $$0(orcid)0000-0002-1284-9007$$aLucia, O.$$uUniversidad de Zaragoza 000132378 700__ $$aMir, L.M. 000132378 7102_ $$15008$$2785$$aUniversidad de Zaragoza$$bDpto. Ingeniería Electrón.Com.$$cÁrea Tecnología Electrónica 000132378 773__ $$g67, 4 (2020), 1040-1049$$pIEEE trans. biomed. eng.$$tIEEE Transactions on Biomedical Engineering$$x0018-9294 000132378 8564_ $$s738974$$uhttps://zaguan.unizar.es/record/132378/files/texto_completo.pdf$$yPostprint 000132378 8564_ $$s3359052$$uhttps://zaguan.unizar.es/record/132378/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint 000132378 909CO $$ooai:zaguan.unizar.es:132378$$particulos$$pdriver 000132378 951__ $$a2024-03-11-09:48:57 000132378 980__ $$aARTICLE